Sexual transmission of Zika virus enhances in utero transmission in a mouse model
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
i

Superseded

This Document Has Been Replaced By:

i

Retired

This Document Has Been Retired

i

Up-to-date Information

This is the latest update:

Sexual transmission of Zika virus enhances in utero transmission in a mouse model
  • Published Date:

    Mar 14 2018

  • Source:
    Sci Rep. 8.
Filetype[PDF-1.36 MB]


Details:
  • Alternative Title:
    Sci Rep
  • Personal Author:
  • Description:
    Zika virus (ZIKV) is an emerging mosquito-borne virus that can cause ZIKV congenital syndrome when a pregnant woman is infected. Sexual transmission has also been described for ZIKV, though the relationship between sexual transmission and vertical transmission has not been investigated. Here, viral dissemination to the female reproductive tract and fetuses was assessed in immunodeficient (AG129) female mice that were exposed to ZIKV by subcutaneous (s.c.) inoculation, intravaginal (ivag.) inoculation, or sexual transmission from infected male AG129 mice. Pregnant females had significantly increased ZIKV dissemination to the female reproductive tract compared to non-pregnant females when exposed by s.c. or ivag. inoculation. Sexual transmission resulted in significantly greater morbidity and mortality in females and higher ZIKV titers in the female reproductive tract than s.c. or ivag. inoculation. Ovaries from females infected sexually contained ZIKV RNA within the ovarian follicles. Furthermore, ZIKV titers were significantly higher in fetuses from dams exposed sexually compared to fetuses from dams exposed by s.c. or ivag. inoculation. These results demonstrate that sexual transmission enhances dissemination of ZIKV to the female reproductive tract and developing fetuses in a mouse model.
  • Subject:
  • Pubmed ID:
    29540804
  • Pubmed Central ID:
    PMC5852059
  • Document Type:
    Journal Article
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
  • File Type:
No Related Documents.

You May Also Like:

  1. Filetype[PDF - 515.45 KB]
    Personal Author:
    Sarkar, Subrata; Shankaran, Seetha; Barks, John; Do, Barbara T.; Laptook, Abbot R.; Das, Abhik; Ambalavanan, Namasivayam; Van Meurs, Krisa P.; Bell, Edward F.; Sanchez, Pablo J.; Hintz, Susan R.; Wyckoff, Myra H.; Stoll, Barbara J.; Carlo, Waldemar A.;
    Published Date:
    Feb 02 2018
    Source:
    J Pediatr. 195:59-65.e3.
    Description:
    ObjectiveTo determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies.Study designInfants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imagi...
    File Type:
    Filetype[PDF - 515.45 KB]
  2. Filetype[PDF - 512.70 KB]
    Personal Author:
    Koman, Patricia D.; Mancuso, Peter;
    Published Date:
    Jun 15 2017
    Source:
    Chem Res Toxicol. 30(7):1384-1395.
    Description:
    From 1999-2014, obesity prevalence increased among adults and youth. Obese individuals may be uniquely susceptible to the proinflammatory effects of ozone because obese humans and animals have been shown to experience a greater decline in lung functi...
    File Type:
    Filetype[PDF - 512.70 KB]
  3. Filetype[PDF - 706.23 KB]
    Personal Author:
    Graham, S; Lewis, B; Flanagan, B; Watson, M; Peipins, L;
    Published Date:
    Dec 2015
    Source:
    J Transp Health. 2(4):602-609.
    Description:
    We examined lack of private vehicle access and 30 minutes or longer public transportation travel time to mammography facilities for women 40 years of age or older in the urban areas of Boston, Philadelphia, San Antonio, San Diego, Denver, and Seattle...
    File Type:
    Filetype[PDF - 706.23 KB]
  4. Filetype[PDF - 1.15 MB]
    Personal Author:
    Sloan, Chantel D.; Andrew, Angeline S.; Gruber, Joann F.; Mwenda, Kevin M.; Moore, Jason H.; Onega, Tracy; Karagas, Margaret R.; Shi, Xun; Duell, Eric J.;
    Published Date:
    Jan 1 2012
    Source:
    Toxicol Environ Chem. 94(3).
    Description:
    Indoor and outdoor air pollution is known to contribute to increased lung cancer incidence. This study is the first to address the contribution of home heating fuel and geographical course particulate matter (PM10) concentrations to lung cancer rates...
    File Type:
    Filetype[PDF - 1.15 MB]
  5. Filetype[PDF - 36.38 KB]
    Personal Author:
    ROSSNER, ALAN; DOTSON, G. SCOTT;
    Published Date:
    Jun 2012
    Source:
    Synergist (Akron). 23:30-31.
    File Type:
    Filetype[PDF - 36.38 KB]