Details:

Alternative Title:
Sci Rep
Personal Author:
Duggal, Nisha K. ; McDonald, Erin M. ; Ritter, Jana M. ; Brault, Aaron C. ;
Duggal, Nisha K. ; McDonald, Erin M. ; Ritter, Jana M. ; Brault, Aaron C. ; Less -
Description:
Zika virus (ZIKV) is an emerging mosquito-borne virus that can cause ZIKV congenital syndrome when a pregnant woman is infected. Sexual transmission has also been described for ZIKV, though the relationship between sexual transmission and vertical transmission has not been investigated. Here, viral dissemination to the female reproductive tract and fetuses was assessed in immunodeficient (AG129) female mice that were exposed to ZIKV by subcutaneous (s.c.) inoculation, intravaginal (ivag.) inoculation, or sexual transmission from infected male AG129 mice. Pregnant females had significantly increased ZIKV dissemination to the female reproductive tract compared to non-pregnant females when exposed by s.c. or ivag. inoculation. Sexual transmission resulted in significantly greater morbidity and mortality in females and higher ZIKV titers in the female reproductive tract than s.c. or ivag. inoculation. Ovaries from females infected sexually contained ZIKV RNA within the ovarian follicles. Furthermore, ZIKV titers were significantly higher in fetuses from dams exposed sexually compared to fetuses from dams exposed by s.c. or ivag. inoculation. These results demonstrate that sexual transmission enhances dissemination of ZIKV to the female reproductive tract and developing fetuses in a mouse model.
Subject:
[+]
Animals
Disease Models, Animal
Female
Infectious Disease Transmission, Vertical
Male
Mice
Pregnancy
RNA, Viral
Uterus
Vagina
Viral Load
Zika Virus
Zika Virus Infection

Source:
Sci Rep. 8. ;
Pubmed ID:
29540804
Pubmed Central ID:
PMC5852059
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ef14a7701fd60575debc3c3f2423c303765be276c2de379cfddbac611d6a0dc1
File Type:

Supporting Files

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