Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Sharp, Tyler M. ; Gaul, Linda ; Muehlenbachs, Atis ; Hunsperger, Elizabeth ; Bhatnagar, Julu ; ... More +
Sharp, Tyler M. ; Gaul, Linda ; Muehlenbachs, Atis ; Hunsperger, Elizabeth ; Bhatnagar, Julu ; Lueptow, Rebekka ; Santiago, Gilberto A. ; Muñoz-Jordan, Jorge L. ; Blau, Dianna M. ; Ettestad, Paul ; Bissett, Jack D. ; Ledet, Suzanne C. ; Zaki, Sherif R. ; Tomashek, Kay M. Less -
Description:
Dengue is caused by infection with any of four mosquito-transmitted dengue viruses (DENV-1-4) and is characterized by fever, headache, myalgia, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that can be familial or acquired, and is characterized by persistent fever, pancytopenia, hepatosplenomegaly, and increased serum ferritin. Acquired HLH is most frequently associated with Epstein Barr virus infection but also has been associated with dengue. This report describes a fatal case of acquired HLH that was apparently triggered by infection with DENV-3. The patient developed an acute febrile illness in August 2012 during a 1-month vacation in New Mexico. After returning to her home in Texas, she was initially diagnosed with West Nile virus (WNV) infection, developed pancytopenia, liver failure, and disseminated intravascular coagulopathy, and died. DENV-3 was detected in a premortem bone marrow biopsy in which erythrophagocytosis was evident. This case underscores the need for clinicians in the United States to be vigilant for dengue and request diagnostic testing for suspected cases, which should be reported to public health authorities.
Subject:
[+]
Articles
Dengue
Fatal Outcome
Female
Humans
Lymphohistiocytosis, Hemophagocytic
Middle Aged

Source:
MMWR Morb Mortal Wkly Rep. 2014; 63(3):49-54.
Pubmed ID:
24452132
Pubmed Central ID:
PMC5779429
Document Type:
Journal Article
Place as Subject:
New Mexico ; Texas
New Mexico ; Texas Less -
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:61e9b0e2859dc37f744c72c40fd2f28d491e80aaf67ac2e98030bf3f7e551e82
File Type:

Supporting Files

• 	49-54.nxml	xml
  	49-54f1.gif	gif
  	49-54f1.jpg	jpeg
  	49-54f2.gif	gif
  	49-54f2.jpg	jpeg
  	49-54f3.gif	gif
  	49-54f3.jpg	jpeg

More +