Nonsteroidal antiinflammatory drug use among women and the risk of birth defects

Details

• Alternative Title:
  Am J Obstet Gynecol
• Personal Author:
  Hernandez, Rohini K. ; Werler, Martha M. ; Romitti, Paul ; Sun, Lixian ; Anderka, Marlene
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  OBJECTIVE ; We examined whether the use of nonsteroidal antiinflammatory drugs (NSAIDs) in early pregnancy was associated with a range of structural birth defects. ; STUDY DESIGN ; Data were from the National Birth Defects Prevention Study, a multisite population-based, case-control study of risk factors for birth defects. ; RESULTS ; Among women in the National Birth Defects Prevention Study, 22.6% reported the use of NSAIDs in the first trimester of pregnancy, most commonly ibuprofen, aspirin, and naproxen. Of the 29 defect groups that were examined, most were not associated with NSAID use. Small-to-moderate increased risks of some oral cleft groups, some neural tube defect groups, anophthalmia/microphthalmia, pulmonary valve stenosis, amniotic bands/limb body wall defects, and transverse limb deficiencies were associated with ibuprofen, aspirin, and naproxen exposure. ; CONCLUSION ; The use of NSAIDs in early pregnancy does not appear to be a major risk factor for birth defects, although there were a few moderate associations between NSAIDs and specific birth defects.
• Subjects:
  • Abnormalities, Drug-Induced
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal
  • Case-Control Studies
  • Congenital Abnormalities
  • Female
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Trimester, First
  More +
• Source:
  Am J Obstet Gynecol. 206(3):228.e1-228.e8.
• Pubmed ID:
  22196851
• Pubmed Central ID:
  PMC5893141
• Document Type:
  Journal Article
• Funding:
  U01 DD000492/DD/NCBDD CDC HHS/United States ; U01DD000493/DD/NCBDD CDC HHS/United States
• Volume:
  206
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/53223/cdc_53223_DS1.pdf
• File Type:
  [PDF - 103.64 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c6776a94edb0bcbe02a53c9ac5b29b585adc3c38e9f3d6cb071341d864498485