Predictors of Dyslipidemia Over Time in Youth With Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Shah, Amy S. ; Maahs, David M. ; Stafford, Jeanette M. ; Dolan, Lawrence M. ; Lang, Wei ; Imperatore, Giuseppina ; Bell, Ronny A. ; Liese, Angela D. ; Reynolds, Kristi ; Pihoker, Catherine ; Marcovina, Santica ; D’Agostino, Ralph B. ; Dabelea, Dana
• Description:
  OBJECTIVE
  
  Understanding the risk factors associated with progression and regression of dyslipidemia in youth with type 1 diabetes may guide treatments.
  
  RESEARCH DESIGN AND METHODS
  
  We studied 1,478 youth with type 1 diabetes (age 10.8 ± 3.9 years, 50% male, 77% non-Hispanic white, not on lipid-lowering medications) at baseline and at a mean follow-up of 7.1 ± 1.9 years in the SEARCH for Diabetes in Youth (SEARCH) study. Progression to dyslipidemia was defined as normal lipid concentrations at baseline and abnormal at follow-up (non–HDL-cholesterol [C] >130 mg/dL or HDL-C <35 mg/dL). Regression was defined as abnormal lipids at baseline and normal at follow-up. Multivariable logistic regression was used to evaluate factors associated with progression and regression compared with stable normal and stable abnormal, respectively. An area under the curve (AUC) variable was used for the time-varying covariates A1C and waist-to-height ratio (WHtR).
  
  RESULTS
  
  Non–HDL-C progressed, regressed, was stable normal, and stable abnormal in 19%, 5%, 69%, and 7% of youth with type 1 diabetes, respectively. Corresponding percentages for HDL-C were 3%, 3%, 94%, and 1%, respectively. Factors associated with non–HDL-C progression were higher A1C AUC and higher WHtR AUC in males. Non–HDL-C regression was associated with lower WHtR AUC, and HDL-C progression was associated with male sex and higher WHtR AUC. HDL-C regression was not modeled due to small numbers.
  
  CONCLUSIONS
  
  A1C and WHtR are modifiable risk factors associated with change in dyslipidemia over time in youth with type 1 diabetes.
  
  
• Subjects:
  Adolescent Body Mass Index Cardiovascular And Metabolic Risk Child Cholesterol, HDL Cholesterol, LDL Diabetes Mellitus, Type 1 Disease Progression Dyslipidemias Female Follow-Up Studies Glycated Hemoglobin A Humans Logistic Models Male Multivariate Analysis Prospective Studies Risk Factors

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• Source:
  Diabetes Care. 2017; 40(4):607-613.
• Pubmed ID:
  28126715
• Pubmed Central ID:
  PMC5360282
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHS/United States ; UC4 DK108173/DK/NIDDK NIH HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U18 DP006131/DP/NCCDPHP CDC HHS/United States ; U18 DP002710/DP/NCCDPHP CDC HHS/United States ; U18 DP006134/DP/NCCDPHP CDC HHS/United States ; U18 DP006138/DP/NCCDPHP CDC HHS/United States ; UL1 TR000154/TR/NCATS NIH HHS/United States ; U18 DP002714/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U18 DP006136/DP/NCCDPHP CDC HHS/United States ; U18 DP002709/DP/NCCDPHP CDC HHS/United States ; U18 DP006133/DP/NCCDPHP CDC HHS/United States ; UL1 TR001425/TR/NCATS NIH HHS/United States ; U18 DP006139/DP/NCCDPHP CDC HHS/United States ; UL1 TR000423/TR/NCATS NIH HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; UL1 TR001450/TR/NCATS NIH HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18 DP002708/DP/NCCDPHP CDC HHS/United States
• Volume:
  40
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:50e211469feb48e96dd383a6696314062ca62ff756080c463fd2ba64dcdedb90
• Download URL:
  https://stacks.cdc.gov/view/cdc/53198/cdc_53198_DS1.pdf
• File Type:
  [PDF - 524.75 KB ]