Details:

Alternative Title:
J Clin Virol
Personal Author:
Malosh, Ryan E. ; Martin, Emily T. ; Callear, Amy P. ; Petrie, Joshua G. ; Lauring, Adam ; ... More +
Malosh, Ryan E. ; Martin, Emily T. ; Callear, Amy P. ; Petrie, Joshua G. ; Lauring, Adam ; Lamerato, Lois ; Fry, Alicia M. ; Ferdinands, Jill ; Flannery, Brendan ; Monto, Arnold S. Less -
Description:
Background

The importance of Respiratory Syncytial Virus (RSV) is increasingly recognized in hospitalized adults, but mainly in those ≥ 65 years.

Objectives

We sought to describe the epidemiology and clinical severity of RSV compared to influenza in hospitalized adults ≥18 years.

Study Design

Adults hospitalized with acute respiratory illnesses (ARI) of ≤10 days duration were prospectively enrolled from two Michigan hospitals during two influenza seasons. Collected specimens were tested for RSV and influenza by real-time, reverse transcription polymerase chain reaction (RT-PCR). Viral load and subtype were determined for RSV-positive specimens. We evaluated factors associated with RSV and outcomes of infection using multivariable logistic regression. RSV-positive patients were separately compared to two reference groups: RSV-negative and influenza-negative, and influenza-positive patients.

Results

RSV was detected in 84 (7%) of 1259 hospitalized individuals (55 RSV-B, 29 RSV-A). The highest prevalence was found in 50-64 year olds (40/460; 8.7%); 98% of RSV cases in this age group had at least one chronic comorbidity. RSV detection was associated with obesity (OR: 1.71 95% CI: 0.99-3.06, p=0.03). Individuals with RSV were admitted to the hospital later in their illness and had a higher median Charlson comborbidity index (3 vs 2 p < 0.001) compared to those with influenza. Clinical severity of RSV-associated hospitalizations was similar to influenza-associated hospitalizations.

Discussion

In this study we observed the highest frequency of RSV-associated hospitalizations among adult 50-64 years old; many of whom had chronic comorbidities. Our results suggest the potential benefit of including these individuals in future RSV vaccination strategies.


Subjects:
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Adolescent Adult Aged Aged, 80 And Over Article Female Hospitalization Hospitals Humans Male Middle Aged Prognosis Prospective Studies Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Treatment Outcome Young Adult
Source:
J Clin Virol. 96:37-43
Pubmed ID:
28942341
Pubmed Central ID:
PMC5889293
Document Type:
Journal Article
Funding:
U01 IP000474/IP/NCIRD CDC HHS/United States ; U01 IP000974/IP/NCIRD CDC HHS/United States ; U01IP000974/ACL HHS/United States ; U01IP000974/ACL HHS/
U01 IP000474/IP/NCIRD CDC HHS/United States ; U01 IP000974/IP/NCIRD CDC HHS/United States ; U01IP000974/ACL HHS/United States ; U01IP000974/ACL HHS/ Less -
Place as Subject:
Michigan
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2f6817f00860c47cb3d9cfcf879827d6d80705f1f925137de381d067d3b8fa70
Download URL:
https://stacks.cdc.gov/view/cdc/53175/cdc_53175_DS1.pdf
File Type:

Supporting Files

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