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Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children’s Oncology Group
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Oct 26 2017
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Source: Occup Environ Med. 75(3):205-211.
[PDF-353.69 KB]
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Alternative Title:Occup Environ Med
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Description:Objectives
We examined associations between parental occupational chemical exposures up to 10 years prior to conception and the risk of sporadic retinoblastoma among offspring.
Methods
In our multicenter study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 years before conception, and mothers one month prior to and during the index pregnancy. An industrial hygienist reviewed all occupational data and assigned an overall exposure score to each job indicating presence of 9 hazardous agents.
Results
We estimated elevated odds ratios for unilateral and bilateral retinoblastoma among offspring of fathers who were exposed to polycyclic aromatic hydrocarbons (PAHs) or paints in the 10 years prior to conception. However, only for exposure to paints did confidence limits exclude the null for bilateral disease (OR: 8.76, 95% CI: 1.32-58.09). Maternal prenatal exposure to at least one of the 9 agents was related to increased risk of unilateral disease in their children (OR: 5.25, 95% CI: 1.14-24.16). Fathers exposed to at least one of the 9 agents and who were ≥30 years of age were at increased risk of having a child diagnosed with bilateral retinoblastoma (OR: 6.59, 95% CI: 1.34-32.42).
Conclusions
Our results suggest a role for several hazardous occupational exposures in the development of childhood retinoblastoma.
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Pubmed ID:29074554
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Pubmed Central ID:PMC5884108
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