Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Isidro, Joana ; Santos, Andrea ; Nunes, Alexandra ; Borges, Vítor ; Silva, Catarina ; Vieira, Luís ; Mendes, Aristides L. ; Serrano, Mónica ; Henriques, Adriano O. ; Gomes, João Paulo ; Oleastro, Mónica
• Description:
  We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
• Subjects:
  Antimicrobial Resistance Bacteria CDI Clostridium Difficile Clostridium Difficile Infection Dispatch Imipenem Resistance Imipenem Resistance In Clostridium Difficile Ribotype 017, Portugal Multidrug Resistance Penicillin-binding Proteins Portugal Ribotype 017

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• Source:
  Emerg Infect Dis. 24(4):741-745.
• Pubmed ID:
  29553322
• Pubmed Central ID:
  PMC5875251
• Document Type:
  Journal Article
• Volume:
  24
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:81f2e4c58fb5bcb933625bb098eb8c775b59978661255b7d02fabcb48e990d5c
• Download URL:
  https://stacks.cdc.gov/view/cdc/53050/cdc_53050_DS1.pdf
• File Type:
  [PDF - 1.98 MB ]