Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Isidro, Joana; Santos, Andrea; Nunes, Alexandra; Borges, Vítor; Silva, Catarina; Vieira, Luís; Mendes, Aristides L.; Serrano, Mónica; Henriques, Adriano O.; Gomes, João Paulo; Oleastro, Mónica

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Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Apr 2018
By Isidro, Joana ; Santos, Andrea ; Nunes, Alexandra ; ...
Source: Emerg Infect Dis. 24(4):741-745.

[PDF-1.98 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Isidro, Joana ; Santos, Andrea ; Nunes, Alexandra ; Borges, Vítor ; Silva, Catarina ; ... More +

Isidro, Joana ; Santos, Andrea ; Nunes, Alexandra ; Borges, Vítor ; Silva, Catarina ; Vieira, Luís ; Mendes, Aristides L. ; Serrano, Mónica ; Henriques, Adriano O. ; Gomes, João Paulo ; Oleastro, Mónica Less -
Description:

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
Subjects:

[+]

Antimicrobial Resistance Bacteria CDI Clostridium Difficile Clostridium Difficile Infection Dispatch Imipenem Resistance Imipenem Resistance In Clostridium Difficile Ribotype 017, Portugal Multidrug Resistance Penicillin-binding Proteins Portugal Ribotype 017
Source:

Emerg Infect Dis. 24(4):741-745.
Pubmed ID:

29553322
Pubmed Central ID:

PMC5875251
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:81f2e4c58fb5bcb933625bb098eb8c775b59978661255b7d02fabcb48e990d5c
Download URL:

https://stacks.cdc.gov/view/cdc/53050/cdc_53050_DS1.pdf
File Type:

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	17-0095-Techapp-s1.pdf	pdf
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