Details:

Alternative Title:
Otolaryngol Head Neck Surg
Publisher's site:
http://dx.doi.org/10.1177/0194599818758247
Personal Author:
Lanzieri, Tatiana M. ; Chung, Winnie ; Leung, Jessica ; Caviness, A. Chantal ; Baumgardner, Jason L. ; ... More +
Lanzieri, Tatiana M. ; Chung, Winnie ; Leung, Jessica ; Caviness, A. Chantal ; Baumgardner, Jason L. ; Blum, Peggy ; Bialek, Stephanie R. ; Demmler-Harrison, Gail ; Less -
Corporate Authors:
for the Congenital Cytomegalovirus Longitudinal Study Group ;
Description:
Objectives Compare hearing trajectories among children with symptomatic and asymptomatic congenital CMV infection through age 18 years and identify brain abnormalities associated with sensorineural hearing loss (SNHL) in asymptomatic case-patients. Study Design Longitudinal prospective cohort study. Setting Tertiary medical center. Subjects and Methods Ninety-six (4 symptomatic and 92 asymptomatic) case-patients identified through hospital-based newborn CMV screening during 1982–1992 and 72 symptomatic case-patients identified through referrals during 1993–2005. We used growth curve modeling to analyze hearing thresholds (0.5–8 kHz) by ear with increasing age and Cox regression to determine abnormal findings on head computed tomography (CT) scan associated with SNHL (hearing threshold ≥25 dB in any audiometric frequency) among asymptomatic case-patients. Results Fifty-six (74%) symptomatic and 20 (22%) asymptomatic case-patients had SNHL: congenital/early-onset SNHL was diagnosed in 78 (51%) and 10 (5%) ears, respectively, and delayed-onset SNHL in 25 (17%) and 20 (11%) ears; 49 (32%) and 154 (84%) ears had normal hearing. In affected ears, all frequency-specific hearing thresholds worsened with age. Congenital/early-onset SNHL was significantly worse (severe-profound range [>70dB]) than delayed-onset SNHL (mild-moderate range [26–55db]). Frequency-specific hearing thresholds were significantly different between symptomatic and asymptomatic case-patients at 0.5–1 kHz but not at higher frequencies (2–8 kHz). Among asymptomatic case-patients, white matter lucency was significantly associated with SNHL by age 5 years (hazard ratio=4.4; 95% confidence interval: 1.3–15.6). Conclusion Congenital/early-onset SNHL frequently resulted in severe to profound loss in both symptomatic and asymptomatic case-patients. White matter lucency in asymptomatic case-patients was significantly associated with SNHL by age 5 years.
Subject:
[+]
Article
Congenital Cytomegalovirus Infection
Sensorineural Hearing Loss

Source:
Otolaryngol Head Neck Surg. 158(4):736-744.
Pubmed ID:
29557247
Pubmed Central ID:
PMC5880689
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States ;
CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7dd48206a7410dec1408c919ff9b55d1c2d5f9f38a0afed8bc9e1e1bcf9edf92
File Type:

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