cytomegalovirus disease

Details

• Alternative Title:
  J Perinatol
• Personal Author:
  Lanzieri, Tatiana M. ; Leung, Jessica ; Caviness, A. Chantal ; Chung, Winnie ; Flores, Marily ; Blum, Peggy ; Bialek, Stephanie R. ; Miller, Jerry A. ; Vinson, Sherry S. ; Turcich, Marie R. ; Voigt, Robert G. ; Demmler-Harrison, Gail
• Description:
  Objective
  
  To assess long-term outcomes of children with symptomatic congenital cytomegalovirus (CMV) disease detected at birth.
  
  Methods
  
  We used Cox regression to assess risk factors for intellectual disability (intelligence quotient <70), sensorineural hearing loss (SNHL; hearing level ≥25 dB in any audiometric frequency), and vision impairment (best corrected visual acuity >20 or based on ophthalmologist report).
  
  Results
  
  Among 76 case-patients followed through median age of 13 (range: 0–27) years, 56 (74%) had SNHL, 31 (43%, n=72) had intellectual disability, and 18 (27%, n=66) had vision impairment; 28 (43%, n=65) had intellectual disability and SNHL with/without vision impairment. Microcephaly was significantly associated with each of the three outcomes. Tissue destruction and dysplastic growth on head computed tomography scan at birth was significantly associated with intellectual disability and SNHL.
  
  Conclusion
  
  Infants with symptomatic congenital CMV disease may develop moderate to severe impairments, which were associated with presence of microcephaly and brain abnormalities.
  
  
• Subjects:
  Adolescent Adult Brain Child Child, Preschool Cytomegalovirus Infections Female Hearing Loss, Sensorineural Humans Infant Infant, Newborn Intellectual Disability Longitudinal Studies Male Microcephaly Multivariate Analysis Proportional Hazards Models Risk Factors Tomography, X-Ray Computed Vision Disorders Young Adult

  More +
• Source:
  J Perinatol. 37(7):875-880.
• Pubmed ID:
  28383538
• Pubmed Central ID:
  PMC5562509
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States
• Place as Subject:
  Georgia
• Volume:
  37
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ca9f91365983d2435d8b397b61305355939f8341c6518e14b106d84b8ebd045e
• Download URL:
  https://stacks.cdc.gov/view/cdc/47617/cdc_47617_DS1.pdf
• File Type:
  [PDF - 94.89 KB ]