Long-term outcomes of children with symptomatic congenital
cytomegalovirus disease

Lanzieri, Tatiana M.; Leung, Jessica; Caviness, A. Chantal; Chung, Winnie; Flores, Marily; Blum, Peggy; Bialek, Stephanie R.; Miller, Jerry A.; Vinson, Sherry S.; Turcich, Marie R.; Voigt, Robert G.; Demmler-Harrison, Gail

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Long-term outcomes of children with symptomatic congenital cytomegalovirus disease

Published Date:

Apr 06 2017

Source:

J Perinatol. 37(7):875-880.

[PDF-94.89 KB]

Details:

Personal Authors:

Lanzieri, Tatiana M. ; Leung, Jessica ; Caviness, A. Chantal ; Chung, Winnie ; Flores, Marily ; ... More ▼

Keywords:

[+]

Pubmed ID:

28383538

Pubmed Central ID:

PMC5562509

Description:

Objective

To assess long-term outcomes of children with symptomatic congenital cytomegalovirus (CMV) disease detected at birth.

Methods

We used Cox regression to assess risk factors for intellectual disability (intelligence quotient <70), sensorineural hearing loss (SNHL; hearing level ≥25 dB in any audiometric frequency), and vision impairment (best corrected visual acuity >20 or based on ophthalmologist report).

Results

Among 76 case-patients followed through median age of 13 (range: 0–27) years, 56 (74%) had SNHL, 31 (43%, n=72) had intellectual disability, and 18 (27%, n=66) had vision impairment; 28 (43%, n=65) had intellectual disability and SNHL with/without vision impairment. Microcephaly was significantly associated with each of the three outcomes. Tissue destruction and dysplastic growth on head computed tomography scan at birth was significantly associated with intellectual disability and SNHL.

Conclusion

Infants with symptomatic congenital CMV disease may develop moderate to severe impairments, which were associated with presence of microcephaly and brain abnormalities.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
M01 RR000188/RR/NCRR NIH HHS/United States
P30 HD024064/HD/NICHD NIH HHS/United States

Supporting Files:

nihms857424.nxml

text/xml

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