Details:

Alternative Title:
Regul Toxicol Pharmacol
Personal Author:
Drew, Nathan M. ; Kuempel, Eileen D. ; Pei, Ying ; Yang, Feng
Drew, Nathan M. ; Kuempel, Eileen D. ; Pei, Ying ; Yang, Feng Less -
Description:
The large and rapidly growing number of engineered nanomaterials (ENMs) presents a challenge to assessing the potential occupational health risks. An initial database of 25 rodent studies including 1929 animals across various experimental designs and material types was constructed to identify materials that are similar with respect to their potency in eliciting neutrophilic pulmonary inflammation, a response relevant to workers. Doses were normalized across rodent species, strain, and sex as the estimated deposited particle mass dose per gram of lung. Doses associated with specific measures of pulmonary inflammation were estimated by modeling the continuous dose-response relationships using benchmark dose modeling. Hierarchical clustering was used to identify similar materials. The 18 nanoscale and microscale particles were classified into four potency groups, which varied by factors of approximately two to 100. Benchmark particles microscale TiO| and crystalline silica were in the lowest and highest potency groups, respectively. Random forest methods were used to identify the important physicochemical predictors of pulmonary toxicity, and group assignments were correctly predicted for five of six new ENMs. Proof-of-concept was demonstrated for this framework. More comprehensive data are needed for further development and validation for use in deriving categorical occupational exposure limits.
Subjects:
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Animals Article Benchmark Dose Modeling Hazard Potency Hierarchical Clustering Lung Nanomaterial Nanostructures Occupational Exposure Occupational Exposure Limit Physicochemical Properties Predictive Modeling Pulmonary Inflammation Random Forest Risk Assessment Silicon Dioxide Titanium
Source:
Regul Toxicol Pharmacol. 89:253-267.
Pubmed ID:
28789940
Pubmed Central ID:
PMC5875420
Document Type:
Journal Article
Funding:
R01 ES016189/ES/NIEHS NIH HHS/United States ; RC2 ES018772/ES/NIEHS NIH HHS/United States ; RC2 ES018741/ES/NIEHS NIH HHS/United States ; P30 ES007033/ES/NIEHS NIH HHS/United States ; RC2 ES018766/ES/NIEHS NIH HHS/United States ; ... More +
R01 ES016189/ES/NIEHS NIH HHS/United States ; RC2 ES018772/ES/NIEHS NIH HHS/United States ; RC2 ES018741/ES/NIEHS NIH HHS/United States ; P30 ES007033/ES/NIEHS NIH HHS/United States ; RC2 ES018766/ES/NIEHS NIH HHS/United States ; R01 ES019311/ES/NIEHS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; RC1 ES018232/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:10feff8fb727fd3a0f5b8846433dd3a73518a8bfb6f7c70f793585109653a698
Download URL:
https://stacks.cdc.gov/view/cdc/52953/cdc_52953_DS1.pdf
File Type:

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