Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009–2011

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Rolfes, Melissa A. ; Gross, F. Liaini ; Flannery, Brendan ; Meyers, Adrienne F. A. ; Luo, Ma ; Bastien, Nathalie ; Fowler, Robert A. ; Katz, Jacqueline M. ; Levine, Min Z. ; Kumar, Anand ; Uyeki, Timothy M.
• Corporate Authors:
  With the CSIS and ROSII Study Groups
• Description:
  Background
  
  The kinetics of the antibody response during severe influenza are not well documented.
  
  Methods
  
  Critically ill patients infected with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), confirmed by reverse-transcription polymerase chain reaction analysis or seroconversion (defined as a ≥4-fold rise in titers), during 2009–2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed-effects models and compared by patient outcome, age, and corticosteroid treatment.
  
  Results
  
  Of 47 patients with A(H1N1)pdm09 virus infection (median age, 47 years), 59% had baseline HAI titers of <40, and 68% had baseline neutralizing titers of <40. Antibody titers rose quickly after symptom onset, and, by day 14, 83% of patients had HAI titers of ≥40, and 80% had neutralizing titers ≥40. Baseline HAI titers were significantly higher in patients who died compared with patients who survived; however, the antibody kinetics were similar by patient outcome and corticosteroid treatment. Geometric mean titers over time in older patients were lower than those in younger patients.
  
  Conclusions
  
  Critically ill patients with influenza A(H1N1)pdm09 virus infection had strong HAI and neutralizing antibody responses during their illness. Antibody kinetics differed by age but were not associated with patient outcome.
  
  
• Subjects:
  Adolescent Adult Aged Antibodies, Viral Article Canada Critical Illness Female Humans Humoral Immunity Influenza Influenza, Human Influenza A Virus, H1N1 Subtype Male Middle Aged Pandemics Risk Factors Seasons Time Factors Young Adult

  More +
• Source:
  J Infect Dis. 217(7):1078-1088
• Pubmed ID:
  29342251
• Pubmed Central ID:
  PMC5856644
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  217
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:71ab7ee65d563bb255637fbbb8b1dac5ea9968fa3e8603f00693d48cf0393472
• Download URL:
  https://stacks.cdc.gov/view/cdc/52626/cdc_52626_DS1.pdf
• File Type:
  [PDF - 515.83 KB ]