Details:

Alternative Title:
J Infect Dis
Personal Author:
Rolfes, Melissa A. ; Gross, F. Liaini ; Flannery, Brendan ; Meyers, Adrienne F. A. ; Luo, Ma ; ... More +
Rolfes, Melissa A. ; Gross, F. Liaini ; Flannery, Brendan ; Meyers, Adrienne F. A. ; Luo, Ma ; Bastien, Nathalie ; Fowler, Robert A. ; Katz, Jacqueline M. ; Levine, Min Z. ; Kumar, Anand ; Uyeki, Timothy M. Less -
Corporate Authors:
With the CSIS and ROSII Study Groups
Description:
Background

The kinetics of the antibody response during severe influenza are not well documented.

Methods

Critically ill patients infected with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), confirmed by reverse-transcription polymerase chain reaction analysis or seroconversion (defined as a ≥4-fold rise in titers), during 2009–2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed-effects models and compared by patient outcome, age, and corticosteroid treatment.

Results

Of 47 patients with A(H1N1)pdm09 virus infection (median age, 47 years), 59% had baseline HAI titers of <40, and 68% had baseline neutralizing titers of <40. Antibody titers rose quickly after symptom onset, and, by day 14, 83% of patients had HAI titers of ≥40, and 80% had neutralizing titers ≥40. Baseline HAI titers were significantly higher in patients who died compared with patients who survived; however, the antibody kinetics were similar by patient outcome and corticosteroid treatment. Geometric mean titers over time in older patients were lower than those in younger patients.

Conclusions

Critically ill patients with influenza A(H1N1)pdm09 virus infection had strong HAI and neutralizing antibody responses during their illness. Antibody kinetics differed by age but were not associated with patient outcome.


Subject:
[+]
Adolescent
Adult
Aged
Antibodies, Viral
Critical Illness
Female
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Male
Middle Aged
Pandemics
Risk Factors
Seasons
Time Factors
Young Adult

Source:
J Infect Dis. 217(7):1078-1088
Pubmed ID:
29342251
Pubmed Central ID:
PMC5856644
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Canada
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:71ab7ee65d563bb255637fbbb8b1dac5ea9968fa3e8603f00693d48cf0393472
File Type:

Supporting Files

• 	NIHMS944787-supplement-Supplemental_Figures.docx	docx
  	nihms944787.nxml	xml
  	nihms944787f1.gif	gif
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