Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000–2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Loutet, Miranda G. ; Davidson, Jennifer A. ; Brown, Tim ; Dedicoat, Martin ; Thomas, H. Lucy ; Lalor, Maeve K.
• Description:
  Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with acquired drug resistance during 2000-2015 among TB patients in England, Wales, and Northern Ireland. We found acquired resistance in 0.2% (158/67,710) of patients with culture-confirmed TB. Using multivariate logistic regression, we identified the following factors associated with acquired drug resistance: having pulmonary disease; initial resistance to isoniazid, rifampin, or both; a previous TB episode; and being born in China or South Africa. Treatment outcomes were worse for patients with than without acquired resistance. Although acquired resistance is rare in the study area, certain patient groups are at higher risk. Identifying these patients and ensuring that adequate resources are available for treatment may prevent acquisition of resistance, thereby limiting transmission of drug-resistant strains of mycobacteria.
• Subjects:
  Adolescent Adult Antitubercular Agents/pharmacology Antitubercular Agents/therapeutic Use Drug Resistance, Bacterial/drug Effects Female History, 21st Century Humans Male Mycobacterium Tuberculosis/drug Effects Research Retrospective Studies Tuberculosis, Multidrug-Resistant/drug Therapy Tuberculosis, Multidrug-Resistant/epidemiology Tuberculosis, Multidrug-Resistant/history Tuberculosis, Multidrug-Resistant/microbiology Tuberculosis/drug Therapy Tuberculosis/epidemiology Tuberculosis/history Tuberculosis/microbiology Young Adult

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• Source:
  Emerg Infect Dis. 24(3):524-533.
• Pubmed ID:
  29460735
• Pubmed Central ID:
  PMC5823342
• Document Type:
  Journal Article
• Place as Subject:
  England ; Northern Ireland ; Wales
• Location:
  Europe
• Volume:
  24
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c13d5ca308ebb404bb680e8d23147bc2d24a103ce5ee1afe67087c1cdd1bb2b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/52191/cdc_52191_DS1.pdf
• File Type:
  [PDF - 755.89 KB ]