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Cholinesterase inhibitors; including pesticides and chemical warfare nerve agents
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  1. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures
    Personal Author:
    Marsillach, Judit; Hsieh, Edward J.; Richter, Rebecca J.; MacCoss, Michael J.; Furlong, Clement E.;
    Published:
    Nov 02 2012
    Source:
    Chem Biol Interact. 2012; 203(1):85-90.
    Description:
    Organophosphorus (OP) compounds include a broad group of toxic chemicals such as insecticides, chemical warfare agents and antiwear agents. The liver cytochromes P450 bioactivate many OPs to potent inhibitors of serine hydrolases. Cholinesterases wer...
    File Type:
    Filetype[PDF - 253.26 KB]
  2. Direct Quantitation of Methyl Phosphonate Adducts to Human Serum Butyrylcholinesterase by Immunomagnetic-UHPLC-MS/MS
    Personal Author:
    Carter, Melissa D.; Crow, Brian S.; Pantazides, Brooke G.; Watson, Caroline M.; Thomas, Jerry D.; Blake, Thomas A.; Johnson, Rudolph C.;
    Published:
    Nov 08 2013
    Source:
    Anal Chem. 85(22):11106-11111.
    Description:
    Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE). The MeP adduct is considered a sign of "aging" a...
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    Filetype[PDF - 632.75 KB]
  3. An Enhanced Butyrylcholinesterase Method to Measure Organophosphorus Nerve Agent Exposure in Humans
    Personal Author:
    Pantazides, Brooke G.; Watson, Caroline M.; Carter, Melissa D.; Crow, Brian S.; Perez, Jonas W.; Blake, Thomas A.; Thomas, Jerry D.; Johnson, Rudolph C.;
    Published:
    Mar 07 2014
    Source:
    Anal Bioanal Chem. 406(21):5187-5194.
    Description:
    Organophosphorus nerve agent (OPNA) adducts to butyrylcholinesterase (BChE) can be used to confirm exposure in humans. A highly accurate method to detect G- and V-series OPNA adducts to BChE in 75 μL of filtered blood, serum, or plasma has been dev...
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    Filetype[PDF - 369.53 KB]
  4. Background document on Gulf War-related research for the health impact of chemical exposures during the Gulf War; a research planning conference, February 28 - March 2, 1999, Atlanta, Georgia
    Personal Author:
    McClure, Peter Roger, 1950-
    Corporate Author:
    National Center for Environmental Health (U.S.), Division of Environmental Hazards and Health Effects., Veteran's Health Activity Working Group.. Centers for Disease Control and Prevention (U.S.). United States, Office of Public Health and Science.. National Institutes of Health (U.S.). United States, Agency for Toxic Substances and Disease Registry..
    Published:
    1999?
    Description:
    The purpose of this document is to provide background information to participants in the upcoming conference.
    File Type:
    Filetype[PDF - 483.74 KB]
  5. PROTEIN ADDUCTS AS BIOMAKERS OF EXPOSURE TO ORGANOPHOSPHORUS COMPOUNDS
    Personal Author:
    Marsillach, Judit; Costa, Lucio G.; Furlong, Clement E.;
    Published:
    Dec 20 2012
    Source:
    Toxicology. 2012; 307:46-54.
    Description:
    Exposure to organophosphorus (OP) compounds can lead to serious neurological damage or death. Following bioactivation by the liver cytochromes P450, the OP metabolites produced are potent inhibitors of serine active-site enzymes including esterases, ...
    File Type:
    Filetype[PDF - 752.61 KB]