Epidemiology and Molecular Identification and Characterization of Mycoplasma pneumoniae, South Africa, 2012–2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Carrim, Maimuna ; Wolter, Nicole ; Benitez, Alvaro J. ; Tempia, Stefano ; du Plessis, Mignon ; Walaza, Sibongile ; Moosa, Fahima ; Diaz, Maureen H. ; Wolff, Bernard J. ; Treurnicht, Florette K. ; Hellferscee, Orienka ; Dawood, Halima ; Variava, Ebrahim ; Cohen, Cheryl ; Winchell, Jonas M. ; von Gottberg, Anne
• Description:
  During 2012-2015, we tested respiratory specimens from patients with severe respiratory illness (SRI), patients with influenza-like illness (ILI), and controls in South Africa by real-time PCR for Mycoplasma pneumoniae, followed by culture and molecular characterization of positive samples. M. pneumoniae prevalence was 1.6% among SRI patients, 0.7% among ILI patients, and 0.2% among controls (p<0.001). Age <5 years (adjusted odd ratio 7.1; 95% CI 1.7-28.7) and HIV infection (adjusted odds ratio 23.8; 95% CI 4.1-138.2) among M. pneumonia-positive persons were associated with severe disease. The detection rate attributable to illness was 93.9% (95% CI 74.4%-98.5%) in SRI patients and 80.7% (95% CI 16.7%-95.6%) in ILI patients. The hospitalization rate was 28 cases/100,000 population. We observed the macrolide-susceptible M. pneumoniae genotype in all cases and found P1 types 1, 2, and a type 2 variant with multilocus variable number tandem repeat types 3/6/6/2, 3/5/6/2, and 4/5/7/2.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Community-Acquired Infections/Epidemiology Community-Acquired Infections/History Community-Acquired Infections/Microbiology Female Genotype History, 21St Century Hospitalization Humans Infant Male Middle Aged Mycoplasma Pneumoniae Pneumonia, Mycoplasma/Epidemiology Pneumonia, Mycoplasma/History Pneumonia, Mycoplasma/Microbiology Population Surveillance Prevalence Research Risk Factors Young Adult

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• Source:
  Emerg Infect Dis. 24(3):506-513.
• Pubmed ID:
  29460736
• Pubmed Central ID:
  PMC5823326
• Document Type:
  Journal Article
• Funding:
  U01 IP001048/IP/NCIRD CDC HHS/United States
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  24
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:efdf5fa89b8659288db37ac296e7516a4446071d75b98cbd6b6079762f40c6fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/52175/cdc_52175_DS1.pdf
• File Type:
  [PDF - 580.31 KB ]