Details:

Alternative Title:
Am J Ind Med
Personal Author:
Park, Robert M.
Description:
Background

Metalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk.

Methods

Using published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation.

Results

Cancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix. With constant workplace MWF exposure of 0.1 mg/m3 over a 45 years working life, the risk of attributable cancer was 3.7% or, excluding the less certain female cancers, 3.1%.

Conclusion

Substantial cancer risks occurred at 0.1 mg/m3 MWF, one fourth of the current NIOSH recommended exposure limit for MWF total particulate. Because ingredients in current MWF remain from earlier formulations, it is likely that some MWF carcinogenicity persists today. Although important changes have occurred, newer agents are being continually introduced with little or no knowledge of chronic health risks.


Subjects:
[+]
Air Pollutants, Occupational Article Auto Workers Brain Neoplasms Breast Neoplasms Carcinogens Esophageal Cancer Esophageal Neoplasms Excess Lifetime Risk Exposure Response Female Humans Inhalation Exposure Laryngeal Cancer Laryngeal Neoplasms Logistic Models Male Metallurgy National Institute For Occupational Safety And Health, U.S. Neoplasms Occupational Diseases Occupational Exposure Risk Assessment United States Uterine Cervical Neoplasms
Source:
Am J Ind Med. 61(3):198-203
Pubmed ID:
29327473
Pubmed Central ID:
PMC5824980
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:07d7ce8e84e08f25061212a56005880ea89a4dae9b79e7a7bdac4ffdc87c6fdc
Download URL:
https://stacks.cdc.gov/view/cdc/52129/cdc_52129_DS1.pdf
File Type:

Supporting Files

• 	NIHMS942136-supplement-Supplemental_File.docx	docx
  	nihms942136.nxml	xml

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