Risk assessment for metalworking fluids and cancer outcomes

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Park, Robert M.
• Description:
  Background
  
  Metalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk.
  
  Methods
  
  Using published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation.
  
  Results
  
  Cancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix. With constant workplace MWF exposure of 0.1 mg/m3 over a 45 years working life, the risk of attributable cancer was 3.7% or, excluding the less certain female cancers, 3.1%.
  
  Conclusion
  
  Substantial cancer risks occurred at 0.1 mg/m3 MWF, one fourth of the current NIOSH recommended exposure limit for MWF total particulate. Because ingredients in current MWF remain from earlier formulations, it is likely that some MWF carcinogenicity persists today. Although important changes have occurred, newer agents are being continually introduced with little or no knowledge of chronic health risks.
  
  
• Subjects:
  Air Pollutants, Occupational Brain Neoplasms Breast Neoplasms Carcinogens Esophageal Neoplasms Female Humans Inhalation Exposure Laryngeal Neoplasms Logistic Models Male Metallurgy National Institute For Occupational Safety And Health, U.S. Neoplasms Occupational Diseases Occupational Exposure Risk Assessment United States Uterine Cervical Neoplasms

  More +
• Keywords:
  Auto Workers Esophageal Cancer Excess Lifetime Risk Exposure Response Laryngeal Cancer
• Source:
  Am J Ind Med. 61(3):198-203
• Pubmed ID:
  29327473
• Pubmed Central ID:
  PMC5824980
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  61
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:07d7ce8e84e08f25061212a56005880ea89a4dae9b79e7a7bdac4ffdc87c6fdc
• Download URL:
  https://stacks.cdc.gov/view/cdc/52129/cdc_52129_DS1.pdf
• File Type:
  [PDF - 348.41 KB ]