Welcome to CDC stacks | Risk assessment for metalworking fluids and cancer outcomes - 52129 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Risk assessment for metalworking fluids and cancer outcomes
  • Published Date:
    Jan 12 2018
  • Source:
    Am J Ind Med. 61(3):198-203.
Filetype[PDF-348.41 KB]


Details:
  • Personal Authors:
  • Pubmed ID:
    29327473
  • Pubmed Central ID:
    PMC5824980
  • Description:
    Background

    Metalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk.

    Methods

    Using published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation.

    Results

    Cancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix. With constant workplace MWF exposure of 0.1 mg/m3 over a 45 years working life, the risk of attributable cancer was 3.7% or, excluding the less certain female cancers, 3.1%.

    Conclusion

    Substantial cancer risks occurred at 0.1 mg/m3 MWF, one fourth of the current NIOSH recommended exposure limit for MWF total particulate. Because ingredients in current MWF remain from earlier formulations, it is likely that some MWF carcinogenicity persists today. Although important changes have occurred, newer agents are being continually introduced with little or no knowledge of chronic health risks.

  • Document Type:
  • Collection(s):
No Related Documents.
You May Also Like: