Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children

Details

• Alternative Title:
  Med Sci Sports Exerc
• Personal Author:
  Chao, Tony ; Porter, Craig ; Herndon, David N. ; Siopi, Aikaterina ; Ideker, Henry ; Mlcak, Ronald P. ; Sidossis, Labros S. ; Suman, Oscar E.
• Description:
  Introduction
  
  Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogues showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared to burned children undergoing the same RET with a placebo.
  
  Methods
  
  We studied 42 severely burned children (7 – 17 years) with severe burns over 30% of the total body surface area. Patients were randomized to placebo (22 control) or to Oxprop (20) and began drug administration within 96 hours of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength (N·m), power (W), VO2peak, body composition, and protein fractional synthetic (FSR) and breakdown (FBR) rates were measured pre- (PRE) and post-RET (POST).
  
  Results
  
  Muscle strength and power, lean body mass and VO2peak increased with RET in both groups (p<0.01). The increase in strength and power was significantly greater in Oxprop vs. control (p<0.01), and strength and power was greater in Oxprop over control POST RET (p<0.05). FSR was significantly higher in Oxprop than control post RET (p<0.01), resulting in improved protein net balance POST RET (p<0.05).
  
  Conclusion
  
  RET improves body composition, muscle function and cardiorespiratory fitness in children recovering from severe burns. Oxprop therapy augments RET-mediated improvements in muscle strength, power, and protein turnover.
  
  
• Subjects:
  Adolescent Article Basal Metabolism Body Composition Burns Cardiorespiratory Fitness Child Exercise Exercise Therapy Female Heart Rate Humans Male Muscle, Skeletal Muscle Strength Oxandrolone Oxygen Consumption Pediatric Propranolol Rehabilitation

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• Source:
  Med Sci Sports Exerc. 50(3):427-435
• Pubmed ID:
  29040226
• Pubmed Central ID:
  PMC5820183
• Document Type:
  Journal Article
• Funding:
  R01 HD049471/HD/NICHD NIH HHS/United States ; R01 AR049877/AR/NIAMS NIH HHS/United States ; U48 DP000043/DP/NCCDPHP CDC HHS/United States ; R01 GM056687/GM/NIGMS NIH HHS/United States ; P50 GM060338/GM/NIGMS NIH HHS/United States ; T32 GM008256/GM/NIGMS NIH HHS/United States ; P30 AG024832/AG/NIA NIH HHS/United States
• Volume:
  50
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5ade08cea8b8d577405b443943d81b96af33719ef48ea8208be8fbbe42fac016
• Download URL:
  https://stacks.cdc.gov/view/cdc/52040/cdc_52040_DS1.pdf
• File Type:
  [PDF - 574.08 KB ]