Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees

Baker, Marissa G.; Simpson, Christopher D.; Sheppard, Lianne; Stover, Bert; Morton, Jackie; Cocker, John; Seixas, Noah

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Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees

Supporting Files

May 23 2014
By Baker, Marissa G. ; Simpson, Christopher D. ; Sheppard, Lianne ; ...

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Alternative Title:

J Trace Elem Med Biol
Personal Author:

Baker, Marissa G. ; Simpson, Christopher D. ; Sheppard, Lianne ; Stover, Bert ; Morton, Jackie ; Cocker, John ; Seixas, Noah
Description:

Various biomarkers of exposure have been explored as a way to quantitatively estimate an internal dose of manganese (Mn) exposure, but given the tight regulation of Mn in the body, inter-individual variability in baseline Mn levels, and variability in timing between exposure and uptake into various biological tissues, identification of a valuable and useful biomarker for Mn exposure has been elusive. Thus, a mixed model estimating variance components using restricted maximum likelihood was used to assess the within- and between-subject variance components in whole blood, plasma, and urine (MnB, MnP, and MnU, respectively) in a group of nine newly-exposed apprentice welders, on whom baseline and subsequent longitudinal samples were taken over a three month period. In MnB, the majority of variance was found to be between subjects (94%), while in MnP and MnU the majority of variance was found to be within subjects (79% and 99%, respectively), even when controlling for timing of sample. While blood seemed to exhibit a homeostatic control of Mn, plasma and urine, with the majority of the variance within subjects, did not. Results presented here demonstrate the importance of repeat measure or longitudinal study designs when assessing biomarkers of Mn, and the spurious associations that could result from cross-sectional analyses.
Subjects:

Air Pollutants, Occupational Article Biomarkers Biomarkers Of Exposure Cohort Studies Demography Humans Limit Of Detection Manganese Occupational Exposure Time Factors Variability Welders Welding Young Adult
Source:

J Trace Elem Med Biol. 2014; 0:123-129.
Pubmed ID:

24916793
Pubmed Central ID:

PMC4241381
Document Type:

Journal Article
Funding:

R01 ES017809/ES/NIEHS NIH HHS/United States ; T42 OH008433/OH/NIOSH CDC HHS/United States ; R01ES017809/ES/NIEHS NIH HHS/United States
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:0ea067d9d57ea8a0d5a6122d20679ffc7445b68bc4fd9062372d13d7653c4b4e
Download URL:

https://stacks.cdc.gov/view/cdc/52009/cdc_52009_DS1.pdf
File Type:

[PDF - 372.09 KB ]

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