Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Divers, Thomas J. ; Tennant, Bud C. ; Kumar, Arvind ; McDonough, Sean ; Cullen, John ; ... More +
Divers, Thomas J. ; Tennant, Bud C. ; Kumar, Arvind ; McDonough, Sean ; Cullen, John ; Bhuva, Nishit ; Jain, Komal ; Chauhan, Lokendra Singh ; Scheel, Troels Kasper Høyer ; Lipkin, W. Ian ; Laverack, Melissa ; Trivedi, Sheetal ; Srinivasa, Satyapramod ; Beard, Laurie ; Rice, Charles M. ; Burbelo, Peter D. ; Renshaw, Randall W. ; Dubovi, Edward ; Kapoor, Amit Less -
Description:
Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
Subject:
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Animals
Cardiovirus Infections
Drug Contamination
Female
Hepatitis, Viral, Animal
Horse Diseases
Horses
Parvoviridae Infections
Phylogeny
Research
Tetanus Antitoxin/adverse Effects
Vaccination/adverse Effects
Viremia

Source:
Emerg Infect Dis. 24(2):303-310.
Pubmed ID:
29350162
Pubmed Central ID:
PMC5782890
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0ec75d0b6fc2ddbf011e3b10283e5cff5973c81a6498652148d957e0193606ab
File Type:

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