New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Divers, Thomas J. ; Tennant, Bud C. ; Kumar, Arvind ; McDonough, Sean ; Cullen, John ; Bhuva, Nishit ; Jain, Komal ; Chauhan, Lokendra Singh ; Scheel, Troels Kasper Høyer ; Lipkin, W. Ian ; Laverack, Melissa ; Trivedi, Sheetal ; Srinivasa, Satyapramod ; Beard, Laurie ; Rice, Charles M. ; Burbelo, Peter D. ; Renshaw, Randall W. ; Dubovi, Edward ; Kapoor, Amit
• Description:
  Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
• Subjects:
  Animals Cardiovirus Infections Drug Contamination Female Hepatitis, Viral, Animal Horse Diseases Horses Parvoviridae Infections Phylogeny Research Tetanus Antitoxin/adverse Effects Vaccination/adverse Effects Viremia

  More +
• Source:
  Emerg Infect Dis. 24(2):303-310.
• Pubmed ID:
  29350162
• Pubmed Central ID:
  PMC5782890
• Document Type:
  Journal Article
• Volume:
  24
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0ec75d0b6fc2ddbf011e3b10283e5cff5973c81a6498652148d957e0193606ab
• Download URL:
  https://stacks.cdc.gov/view/cdc/51383/cdc_51383_DS1.pdf
• File Type:
  [PDF - 2.00 MB ]