Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013

Scully, Erik J.; Basnet, Sarmi; Wrangham, Richard W.; Muller, Martin N.; Otali, Emily; Hyeroba, David; Grindle, Kristine A.; Pappas, Tressa E.; Thompson, Melissa Emery; Machanda, Zarin; Watters, Kelly E.; Palmenberg, Ann C.; Gern, James E.; Goldberg, Tony L.

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Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013

Supporting Files Public Domain

Feb 2018
By Scully, Erik J. ; Basnet, Sarmi ; Wrangham, Richard W. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Scully, Erik J. ; Basnet, Sarmi ; Wrangham, Richard W. ; Muller, Martin N. ; Otali, Emily ; Hyeroba, David ; Grindle, Kristine A. ; Pappas, Tressa E. ; Thompson, Melissa Emery ; Machanda, Zarin ; Watters, Kelly E. ; Palmenberg, Ann C. ; Gern, James E. ; Goldberg, Tony L.
Description:

We describe a lethal respiratory outbreak among wild chimpanzees in Uganda in 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout the respiratory tract; other pathogens were absent. Epidemiologic modeling estimated the basic reproductive number (R0) for the epidemic as 1.83, consistent with the common cold in humans. Genotyping of 41 chimpanzees and examination of 24 published chimpanzee genomes from subspecies across Africa showed universal homozygosity for the cadherin-related family member 3 CDHR3-Y529 allele, which increases risk for rhinovirus C infection and asthma in human children. These results indicate that chimpanzees exhibit a species-wide genetic susceptibility to rhinovirus C and that this virus, heretofore considered a uniquely human pathogen, can cross primate species barriers and threatens wild apes. We advocate engineering interventions and prevention strategies for rhinovirus infections for both humans and wild apes.
Subjects:

Anthroponoses Asthma Cadherin CDHR3 CDHR3-C529 CDHR3-Y529 Chimpanzee Common Cold Enterovirus Epidemic Epidemiology Human Rhinovirus Outbreak Picornaviridae Research Respiratory Disease Respiratory Infections Rhinovirus Rhinovirus C Virology Viruses Zoonoses
Source:

Emerg Infect Dis. 24(2):267-274.
Pubmed ID:

29350142
Pubmed Central ID:

PMC5782908
Document Type:

Journal Article
Place as Subject:

Uganda
Location:

Africa
Volume:

24
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:1a4a170fda5142eb382470bf31a008756df4925e4aed9f858208fefbad66c824
Download URL:

https://stacks.cdc.gov/view/cdc/51374/cdc_51374_DS1.pdf
File Type:

[PDF - 1.52 MB ]

File Language:

English

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