Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

Details

• Alternative Title:
  Breast Cancer Res
• Personal Author:
  Ma, Huiyan ; Ursin, Giske ; Xu, Xinxin ; Lee, Eunjung ; Togawa, Kayo ; Malone, Kathleen E. ; Marchbanks, Polly A. ; McDonald, Jill A. ; Simon, Michael S. ; Folger, Suzanne G. ; Lu, Yani ; Sullivan-Halley, Jane ; Deapen, Dennis M. ; Press, Michael F. ; Bernstein, Leslie
• Description:
  Background
  
  Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes defined by the tumor protein expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
  
  Methods
  
  We evaluated the associations of body mass index (BMI) at age 18 years and recent BMI in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes, in 6320 women (3934 case-patient participants, 2386 control participants) aged 35–64 years, who participated in one of three population-based case-control studies. We estimated multivariable-adjusted odd ratios (ORs) and corresponding 95% confidence intervals (CIs) using polychotomous unconditional logistic regression methods for case-control comparisons in premenopausal women and postmenopausal women.
  
  Results
  
  BMI at age 18 years was inversely associated with risk of breast cancer, particularly among premenopausal women (≥ 25 vs. < 20 kg/m2, OR = 0.72, 95% CI = 0.53–0.96; per 5 kg/m2 increase, OR = 0.83, 95% CI = 0.73–0.95). This inverse association did not differ across ER/PR/HER2-defined subtypes or by race (white women, African-American women). Recent BMI was not associated with risk of premenopausal breast cancer after adjustment for BMI at age 18 years; nevertheless, the analysis for the joint effects of BMI at age 18 years and recent BMI showed that premenopausal women in the highest categories of the two BMI measures (≥ 25 kg/m2 at age 18 years and ≥ 30 kg/m2 for recent BMI) had 46% lower risk of breast cancer than premenopausal women in the lowest categories of the two BMI measures (< 20 kg/m2 at age 18 years and < 25 kg/m2 for recent BMI; OR = 0.54, 95% CI = 0.38–0.78). Neither measure of BMI was statistically significantly associated with risk of postmenopausal breast cancer.
  
  Conclusion
  
  Our findings indicate that high BMI near the end of adolescence decreases risk of all ER/PR/HER2-defined subtypes of premenopausal breast cancer and also suggest that this benefit could be maximized among premenopausal women who consistently have high BMI during their premenopausal years.
  
  
• Subjects:
  Adolescent Adult Black Or African American/genetics Body Mass Index Breast Neoplasms Female Humans Middle Aged Obesity Receptor, ErbB-2 Receptors, Estrogen Receptors, Progesterone Risk Factors White People/genetics Young Adult

  More +
• Source:
  Breast Cancer Res. 20.
• Pubmed ID:
  29357906
• Pubmed Central ID:
  PMC5778748
• Document Type:
  Journal Article
• Funding:
  N01 PC067010/PC/NCI NIH HHS/United States ; K05-CA136967/National Cancer Institute/United States ; Y01 HD007022/HD/NICHD NIH HHS/United States ; N01 CN065064/CN/NCI NIH HHS/United States ; R03 CA188549/CA/NCI NIH HHS/United States ; K05 CA136967/CA/NCI NIH HHS/United States ; R01 CA074847/CA/NCI NIH HHS/United States ; P01 CA017054/CA/NCI NIH HHS/United States ; R03CA188549/National Cancer Institute/United States ; N01PC35139/CA/NCI NIH HHS/United States
• Volume:
  20
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:561828614eb92dbfe977025f7d42f06abdf40f722c2f585eb5dbbbb9ecfda2ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/51331/cdc_51331_DS1.pdf
• File Type:
  [PDF - 457.79 KB ]