Details:

Alternative Title:
J Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/infdis/jiu679
Personal Author:
Harrison, Lee H. ; Shutt, Kathleen A. ; Arnold, Kathryn E. ; Stern, Eric J. ; Pondo, Tracy ; ... More +
Harrison, Lee H. ; Shutt, Kathleen A. ; Arnold, Kathryn E. ; Stern, Eric J. ; Pondo, Tracy ; Kiehlbauch, Julia A. ; Myers, Robert A. ; Hollick, Rosemary A. ; Schmink, Susanna ; Vello, Marianne ; Stephens, David S. ; Messonnier, Nancy E. ; Mayer, Leonard ; Clark, Thomas A. Less -
Description:
Background

Meningococcal disease incidence in the U.S. is at an all-time low. In a previous study of Georgia high school students, meningococcal carriage prevalence was 7%. The purpose of this study was to measure the impact of a meningococcal conjugate vaccine on serogroup Y meningococcal carriage and to define the dynamics of carriage in high school students.

Methods

This was a prospective cohort study at 8 high schools, 4 each in Maryland and Georgia during a school year. In each state, 2 high schools were randomized for participating students to receive MCV4-DT at the beginning of the study and 2 at the end. Oropharyngeal swab cultures for meningococcal carriage were performed three times during the school year.

Results

Among 3,311 students, prevalence of meningococcal carriage was 3.21%–4.01%. Phenotypically non-groupable strains accounted for 88% of carriage isolates. There were only 5 observed acquisitions of serogroup Y strains during the study; therefore, the impact of MCV4-DT on meningococcal carriage could not be determined.

Conclusions

Meningococcal carriage rates in U.S. high school students were lower than expected and the vast majority of strains did not express capsule. These findings may help explain the historically low incidence of meningococcal disease in the U.S.


Subjects:
[+]
Adolescent Adult Article Carrier State Female Humans Male Meningococcal Infections Meningococcal Vaccines Neisseria Meningitidis Prospective Studies Risk Factors Students Young Adult
Source:
J Infect Dis. 211(11):1761-1768
Pubmed ID:
25505298
Pubmed Central ID:
PMC5783552
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Georgia ; Maryland
Georgia ; Maryland Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:95ae3897b6ef7e6c2063cfb244b6392d6c6bafd6fdc3e2a7b94912512b27c301
Download URL:
https://stacks.cdc.gov/view/cdc/51160/cdc_51160_DS1.pdf
File Type:

Supporting Files

• 	NIHMS930256-supplement-Data.xls	xls
  	nihms930256.nxml	xml
  	nihms930256f1.gif	gif
  	nihms930256f1.jpg	jpeg

More +