Details:

Alternative Title:
J Occup Environ Hyg
Publisher's site:
http://dx.doi.org/10.1080/15459624.2016.1252846
Personal Author:
LeBouf, Ryan ; Simmons, Michael
LeBouf, Ryan ; Simmons, Michael Less -
Description:
Gas chromatography/mass spectrometry (GC/MS) operated in selected ion monitoring mode was used to enhance the sensitivity of OSHA Methods 1013/1016 for measuring diacetyl and 2,3-pentanedione in air samples. The original methods use flame ionization detection which cannot achieve the required sensitivity to quantify samples at or below the NIOSH recommended exposure limits (REL: 5 ppb for diacetyl and 9.3 ppb for 2,3-pentanedione) when sampling for both diacetyl and 2,3-pentanedione. OSHA Method 1012 was developed to measure diacetyl at lower levels but requires an electron capture detector, and a sample preparation time of 36 hours. Using GC/MS allows detection of these two alpha-diketones at lower levels than OSHA Method 1012 for diacetyl and OSHA Method 1016 for 2,3-pentanedione. Acetoin and 2,3-hexanedione may also be measured using this technique. Method quantification limits were 1.1 ppb for diacetyl (22% of the REL), 1.1 ppb for 2,3-pentanedione (12% of the REL), 1.1 ppb for 2,3-hexanedione, and 2.1 ppb for acetoin. Average extraction efficiencies above the limit of quantitation were 100% for diacetyl, 92% for 2,3-pentanedione, 89% for 2,3-hexanedione, and 87% for acetoin. Mass spectrometry with OSHA Methods 1013/1016 could be used by analytical laboratories to provide more sensitive and accurate measures of exposure to diacetyl and 2,3-pentanedione.
Subject:
[+]
Environmental Monitoring
Gas Chromatography-Mass Spectrometry
Occupational Exposure
Pentanones

Source:
J Occup Environ Hyg. 14(5):343-348.
Pubmed ID:
27792470
Pubmed Central ID:
PMC5778437
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Name as Subject:
National Institute for Occupational Safety and Health. ; United States. Occupational Safety and Health Administration.
National Institute for Occupational Safety and Health. ; United States. Occupational Safety and Health Administration. Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f928a6bee195e401f9be36f34054755edb426f86fcc843f90a80af1d0e3fd8e4
File Type:

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