Increased sensitivity of OSHA method analysis of diacetyl and 2,3-pentanedione in air

Details

• Alternative Title:
  J Occup Environ Hyg
• Personal Author:
  LeBouf, Ryan ; Simmons, Michael
• Description:
  Gas chromatography/mass spectrometry (GC/MS) operated in selected ion monitoring mode was used to enhance the sensitivity of OSHA Methods 1013/1016 for measuring diacetyl and 2,3-pentanedione in air samples. The original methods use flame ionization detection which cannot achieve the required sensitivity to quantify samples at or below the NIOSH recommended exposure limits (REL: 5 ppb for diacetyl and 9.3 ppb for 2,3-pentanedione) when sampling for both diacetyl and 2,3-pentanedione. OSHA Method 1012 was developed to measure diacetyl at lower levels but requires an electron capture detector, and a sample preparation time of 36 hours. Using GC/MS allows detection of these two alpha-diketones at lower levels than OSHA Method 1012 for diacetyl and OSHA Method 1016 for 2,3-pentanedione. Acetoin and 2,3-hexanedione may also be measured using this technique. Method quantification limits were 1.1 ppb for diacetyl (22% of the REL), 1.1 ppb for 2,3-pentanedione (12% of the REL), 1.1 ppb for 2,3-hexanedione, and 2.1 ppb for acetoin. Average extraction efficiencies above the limit of quantitation were 100% for diacetyl, 92% for 2,3-pentanedione, 89% for 2,3-hexanedione, and 87% for acetoin. Mass spectrometry with OSHA Methods 1013/1016 could be used by analytical laboratories to provide more sensitive and accurate measures of exposure to diacetyl and 2,3-pentanedione.
• Subjects:
  Diacetyl Environmental Monitoring Gas Chromatography-Mass Spectrometry Occupational Exposure Pentanones
• Source:
  J Occup Environ Hyg. 14(5):343-348.
• Pubmed ID:
  27792470
• Pubmed Central ID:
  PMC5778437
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Name as Subject:
  National Institute for Occupational Safety and Health (U.S.) ; United States. Occupational Safety and Health Administration.
• Place as Subject:
  United States
• Volume:
  14
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f928a6bee195e401f9be36f34054755edb426f86fcc843f90a80af1d0e3fd8e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/51149/cdc_51149_DS1.pdf
• File Type:
  [PDF - 1.24 MB ]