Details:

Alternative Title:
Anal Bioanal Chem
Personal Author:
LeBouf, Ryan F. ; Burns, Dru A. ; Ranpara, Anand ; Attfield, Kathleen ; Zwack, Leonard ; ... More +
LeBouf, Ryan F. ; Burns, Dru A. ; Ranpara, Anand ; Attfield, Kathleen ; Zwack, Leonard ; Stefaniak, Aleksandr B. Less -
Description:
The use of electronic nicotine delivery systems continues to gain popularity, and there is concern for potential health risks from inhalation of aerosol and vapor produced by these devices. An analytical method was developed that provided quantitative and qualitative chemical information for characterizing the volatile constituents of bulk electronic cigarette liquids (e-liquids) using a static headspace technique. Volatile organic compounds (VOCs) were screened from a convenience sample of 146 e-liquids by equilibrating 1 g of each e-liquid in amber vials for 24 h at room temperature. Headspace was transferred to an evacuated canister and quantitatively analyzed for 20 VOCs as well as tentatively identified compounds using a preconcentrator/gas chromatography/mass spectrometer system. The e-liquids were classified into flavor categories including brown, fruit, hybrid dairy, menthol, mint, none, tobacco, and other. 2,3-Butanedione was found at the highest concentration in brown flavor types, but was also found in fruit, hybrid dairy, and menthol flavor types. Benzene was observed at concentrations that are concerning given the carcinogenicity of this compound (max 1.6 ppm in a fruit flavor type). The proposed headspace analysis technique coupled with partition coefficients allows for a rapid and sensitive prediction of the volatile content in the liquid. The technique does not require onerous sample preparation, dilution with organic solvents, or sampling at elevated temperatures. Static headspace screening of e-liquids allows for the identification of volatile chemical constituents which is critical for identifying and controlling emission of potentially hazardous constituents in the workplace.
Keywords:
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Benzene Diacetyl Electronic Cigarette Liquids Electronic Nicotine Delivery Systems Gas Chromatography-Mass Spectrometry Gas Chromatography Mass Spectrometry Headspace Menthol Partition Coefficients Solvents Volatile Organic Compounds
Source:
Anal Bioanal Chem. 410(23):5951-5960
Pubmed ID:
29974153
Pubmed Central ID:
PMC6129974
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b12cb082c325582b3d8025a5e88d2d9c1bff76fcf8208f1ef91d590f0d1ad0a3
Download URL:
https://stacks.cdc.gov/view/cdc/58861/cdc_58861_DS1.pdf
File Type:

Supporting Files

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