Details:

Alternative Title:
J Clin Gastroenterol
Personal Author:
Gordon, Stuart C. ; Trudeau, Sheri ; Li, Jia ; Zhou, Yueren ; Rupp, Loralee B. ; ... More +
Gordon, Stuart C. ; Trudeau, Sheri ; Li, Jia ; Zhou, Yueren ; Rupp, Loralee B. ; Holmberg, Scott D. ; Moorman, Anne C. ; Spradling, Philip R. ; Teshale, Eyasu ; Boscarino, Joseph A. ; Daida, Yihe G. ; Schmidt, Mark A. ; Lu, Mei Less -
Description:
Goals

To determine the impact of geography and patient characteristics on hepatitis C virus (HCV) genotype and subtype distribution in a large sample of patients under routine clinical care

Background

HCV genotype impacts disease course and response to treatment. Although several studies have reported genotype distribution within specific US populations, there are no comprehensive descriptions in large, geographically diverse cohorts.

Study

Using data from the Chronic Hepatitis Cohort Study, we present the distribution of HCV genotypes (GT) and subtypes (ST) among a racially diverse cohort of over 8000 HCV-infected patients from four large US health systems.

Results

Genotype distribution varied significantly by geographic and demographic factors. In age-adjusted analyses, African American patients had significantly higher prevalence of GT1 (85%) than other racial categories, largely driven by a markedly higher proportion of GT1 subtype b (~34%) than in Asian/other (24%) and white (21%) patients. GT3 represented an increasing proportion of infections as birth decade progressed, from 4% in patients born before 1946 to 18% of those born after 1976. Within the cohort of “living/uncured” patients, highly elevated alanine aminotransferase (> 2 times the upper limit of normal) was significantly more common in GT3 patients, whereas Fibrosis-4 Index scores indicative of cirrhosis were most common in the combined group of GT4&6 patients.

Conclusion

Distribution of HCV genotypes and subtypes in the United States is more variable than suggested by previous national-level estimates and single-center studies. “Real-world” prevalence data may improve targeting of prevention, screening, and treatment efforts for hepatitis C.


Subject:
[+]
ALT
Article
Genotype 1b
Genotype 3
HCV
Racial Disparities

Source:
J Clin Gastroenterol. 53(1):40-50
Pubmed ID:
28737649
Pubmed Central ID:
PMC5776051
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States
CC999999/ImCDC/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a7665f6b6395dd99d8952253315331986e0eaca7a5e42235959ce2b3288ffd91
File Type:

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