Details:

Alternative Title:
Ann Intern Med
Publisher's site:
http://dx.doi.org/10.7326/M13-1133
Personal Author:
Denniston, Maxine M. ; Jiles, Ruth B. ; Drobeniuc, Jan ; Klevens, R. Monina ; Ward, John W. ; ... More +
Denniston, Maxine M. ; Jiles, Ruth B. ; Drobeniuc, Jan ; Klevens, R. Monina ; Ward, John W. ; McQuillan, Geraldine M. ; Holmberg, Scott D. Less -
Description:
Background

Knowledge of the number of persons with chronic hepatitis C virus (HCV) infection in the United States is critical for public health and policy planning.

Objective

To estimate the prevalence of chronic HCV infection between 2003 and 2010 and to identify factors associated with this condition.

Design

Nationally representative household survey.

Setting

U.S. noninstitutionalized civilian population.

Participants

30 074 NHANES (National Health and Nutrition Examination Survey) participants between 2003 and 2010.

Measurements

Interviews to ascertain demographic characteristics and possible risks and exposures for HCV infection. Serum samples from participants aged 6 years or older were tested for antibody to HCV; if results were positive or indeterminate, the samples were tested for HCV RNA, which indicates current chronic infection.

Results

Based on 273 participants who tested positive for HCV RNA, the estimated prevalence of HCV infection was 1.0% (95% CI, 0.8% to 1.2%), corresponding to 2.7 million chronically infected persons (CI, 2.2 to 3.2 million persons) in the U.S. noninstitutionalized civilian population. Infected persons were more likely to be aged 40 to 59 years, male, and non-Hispanic black and to have less education and lower family income. Factors significantly associated with chronic HCV infection were illicit drug use (including injection drugs) and receipt of a blood transfusion before 1992; 49% of persons with HCV infection did not report either risk factor.

Limitation

Incarcerated and homeless persons were not surveyed.

Conclusion

This analysis estimated that approximately 2.7 million U.S. residents in the population sampled by NHANES have chronic HCV infection, about 500 000 fewer than estimated in a similar analysis between 1999 and 2002. These data underscore the urgency of identifying the millions of persons who remain infected and linking them to appropriate care and treatment.

Primary Funding Source

None.


Subject:
[+]
Adult
Article
Female
Hepacivirus
Hepatitis C, Chronic
Hepatitis C Antibodies
Humans
Male
Middle Aged
Nutrition Surveys
Prevalence
Risk Factors
RNA, Viral
Substance-Related Disorders
Transfusion Reaction
Young Adult

Source:
Ann Intern Med. 160(5):293-300
Pubmed ID:
24737271
Pubmed Central ID:
PMC4562398
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5bb0a958e39672792c8630c7b69eb85c9737356975f68b84567ffbfcb0c74b3b
File Type:

Supporting Files

• 	nihms-718219-f0001.gif	gif
  	nihms-718219-f0001.jpg	jpeg
  	nihms-718219.nxml	xml

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