responses to previously encountered antigens in children

Florek, Kelsey R.; Campos, Luiza M.; Braun, Katarina M.; McLean, Huong Q.; King, Jennifer P.; Flannery, Brendan; Belongia, Edward A.; Friedrich, Thomas C.

doi:10.1016/j.vaccine.2017.12.024

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

i

responses to previously encountered antigens in children

1 29 2018
By Florek, Kelsey R. ; Campos, Luiza M. ; Braun, Katarina M. ; ...
http://dx.doi.org/10.1016/j.vaccine.2017.12.024
Source: Vaccine. 36(5):758-764

[PDF-511.78 KB]

English

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Details:

Alternative Title:

Vaccine
Personal Author:

Florek, Kelsey R. ; Campos, Luiza M. ; Braun, Katarina M. ; McLean, Huong Q. ; King, Jennifer P. ; ... More +

Florek, Kelsey R. ; Campos, Luiza M. ; Braun, Katarina M. ; McLean, Huong Q. ; King, Jennifer P. ; Flannery, Brendan ; Belongia, Edward A. ; Friedrich, Thomas C. Less -
Description:

Background

Influenza vaccination may provide a “back-boost” to antibodies against previously encountered strains. If the back-boost effect is common, this could allow more aggressive vaccine updates, as emerging variants would be expected to both elicit de-novo responses and boost pre-existing responses against recently circulating strains. Here we used the emergence of an antigenically novel A(H3N2) strain to determine whether an antigenically updated vaccine boosted antibodies against historical strains.

Methods

We performed hemagglutination-inhibition (HI) assays on pre- and post-vaccination sera from 124 children 5–17 years old who received 2015–2016 inactivated influenza vaccine, containing an antigenically updated A(H3N2) strain. We evaluated the mean fold increase in HI titer against both the 2015–2016 vaccine strain and representative strains from two prior antigenic clusters. Factors associated with post-vaccination titers against historical strains were evaluated using linear regression, adjusting for baseline titer.

Results

Geometric mean titers against each antigen examined increased significantly after vaccination (P <0.0001). Mean fold increase was 3.29 against the vaccine strain and 1.22–1.46 against historical strains. Response to vaccine strain was associated with increased post-vaccination titers against historical strains.

Conclusions

A vaccine containing an antigenically novel A(H3N2) strain modestly boosted antibody responses against historical influenza strains in children.
Subjects:

[+]

Adolescent Antibodies, Viral Antigens, Viral Article Back-boost Child Child, Preschool Cross Reactions Female Hemagglutination Inhibition Tests Humans Immunogenicity, Vaccine Influenza Influenza, Human Influenza A Virus, H3N2 Subtype Influenza Vaccines Male Outcome Assessment, Health Care Pediatrics Vaccination Vaccine
Source:

Vaccine. 36(5):758-764
Pubmed ID:

29249543
Pubmed Central ID:

PMC5773382
Document Type:

Journal Article
Funding:

C06 RR020141/RR/NCRR NIH HHSUnited States/ ; C06 RR015459/RR/NCRR NIH HHSUnited States/ ; T32 GM007215/GM/NIGMS NIH HHSUnited States/ ; T32 GM008692/GM/NIGMS NIH HHSUnited States/ ; U01 IP000471/IP/NCIRD CDC HHSUnited States/ ; ... More +

C06 RR020141/RR/NCRR NIH HHSUnited States/ ; C06 RR015459/RR/NCRR NIH HHSUnited States/ ; T32 GM007215/GM/NIGMS NIH HHSUnited States/ ; T32 GM008692/GM/NIGMS NIH HHSUnited States/ ; U01 IP000471/IP/NCIRD CDC HHSUnited States/ ; U01 IP001038/IP/NCIRD CDC HHSUnited States/ Less -
Volume:

36
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:7e7971306c437d23925336f8087fa737c111bd3ae6c8efa503952cd758e070cc
Download URL:

https://stacks.cdc.gov/view/cdc/51040/cdc_51040_DS1.pdf
File Type:

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