Characterization of a Feline Influenza A(H7N2) Virus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hatta, Masato ; Zhong, Gongxun ; Gao, Yuwei ; Nakajima, Noriko ; Fan, Shufang ; Chiba, Shiho ; Deering, Kathleen M. ; Ito, Mutsumi ; Imai, Masaki ; Kiso, Maki ; Nakatsu, Sumiho ; Lopes, Tiago J. ; Thompson, Andrew J. ; McBride, Ryan ; Suarez, David L. ; Macken, Catherine A. ; Sugita, Shigeo ; Neumann, Gabriele ; Hasegawa, Hideki ; Paulson, James C. ; Toohey-Kurth, Kathy L. ; Kawaoka, Yoshihiro
• Description:
  During December 2016-February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions. Direct contact transmission of feline H7N2 subtype viruses was detected in ferrets and cats; in cats, exposed animals were also infected via respiratory droplet transmission. These results suggest that the feline H7N2 subtype viruses could spread among cats and also infect humans. Outbreaks of the feline H7N2 viruses could, therefore, pose a risk to public health.
• Subjects:
  Animals Cat Diseases Female Ferrets Humans Influenza, Human Influenza, Human/virology Influenza A Virus, H7N2 Subtype Mice, Inbred BALB C Orthomyxoviridae Infections Phylogeny Research Virus Cultivation

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• Source:
  Emerg Infect Dis. 24(1):75-86.
• Pubmed ID:
  29260686
• Pubmed Central ID:
  PMC5749472
• Document Type:
  Journal Article
• Funding:
  R01 AI114730/AI/NIAID NIH HHS/United States
• Place as Subject:
  New York City, NY
• Location:
  North America
• Volume:
  24
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9b59ef33e7b6abb5c03282eed00b10ecf7b63eb92c1d2bc72197374e3a1907c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/50955/cdc_50955_DS1.pdf
• File Type:
  [PDF - 5.90 MB ]