Objectively Measured Physical Activity and Risk of Knee Osteoarthritis

Details

• Alternative Title:
  Med Sci Sports Exerc
• Personal Author:
  Qin, Jin ; Barbour, Kamil E. ; Nevitt, Michael C. ; Helmick, Charles G. ; Hootman, Jennifer M. ; Murphy, Louise B. ; Cauley, Jane A. ; Dunlop, Dorothy D.
• Description:
  Purpose
  
  To examine the association between objectively measured physical activity and risk of developing incident knee osteoarthritis (OA) in a community-based cohort of middle-aged and older adults.
  
  Methods
  
  We used data from the Osteoarthritis Initiative (OAI), an ongoing prospective cohort study of adults aged 45 to 83 at initial enrollment with elevated risk of symptomatic knee OA. Moderate-vigorous physical activity (MVPA) was measured by a uniaxial accelerometer for seven continuous days in two data collection cycles, and was categorized as inactive (<10 minutes/week), low activity (10–<150 minutes/week), and active (≥150 minutes/week). Incident knee OA based on radiographic and symptomatic OA and joint space narrowing were analyzed as outcomes over four years of follow-up. Participants free of the outcome of interest in both knees at study baseline were included (sample sizes ranged from 694 to 1,331 for different outcomes). We estimated hazard ratio (HR) and its 95% confidence intervals (CI).
  
  Results
  
  In multivariate adjusted analyses, active MVPA participation was not significantly associated with risk of incident radiographic knee OA (HR: 1.52; 95% CI: 0.68–3.40), symptomatic knee OA (HR: 1.17; 95% CI: 0.44–3.09), or joint space narrowing (HR: 0.87; 95% CI: 0.37–2.06), when compared with inactive MVPA participation. Similar results were found for participants with low activity MVPA.
  
  Conclusion
  
  MVPA was not associated with the risk of developing incident knee OA or joint space narrowing over four years of follow-up among OAI participants who are at increased risk of knee OA.
  
  
• Subjects:
  Accelerometer Accelerometry Aged Aged, 80 And Over Article Cohort Study Exercise Follow-Up Studies Humans Knee OA Middle Aged Multivariate Analysis Osteoarthritis, Knee Physical Activity Prospective Studies Risk Factors

  More +
• Source:
  Med Sci Sports Exerc. 50(2):277-283
• Pubmed ID:
  28976494
• Pubmed Central ID:
  PMC5768460
• Document Type:
  Journal Article
• Funding:
  N01AR22263/AR/NIAMS NIH HHS/United States ; R21 AR059412/AR/NIAMS NIH HHS/United States ; N01AR22258/AR/NIAMS NIH HHS/United States ; N01AR22260/AR/NIAMS NIH HHS/United States ; N01AR22262/AR/NIAMS NIH HHS/United States ; R01 AR055287/AR/NIAMS NIH HHS/United States ; P60 AR048098/AR/NIAMS NIH HHS/United States ; N01AR22261/AR/NIAMS NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; R01 AR054155/AR/NIAMS NIH HHS/United States ; N01AR22259/AR/NIAMS NIH HHS/United States
• Volume:
  50
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ad7255d44a913d9508d3f9533f53f84ab970fb40b204ef0eb120e0aad76c0821
• Download URL:
  https://stacks.cdc.gov/view/cdc/50878/cdc_50878_DS1.pdf
• File Type:
  [PDF - 469.88 KB ]