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Longitudinal and Cross-sectional Analyses of Lung Function in Toluene Diisocyanate Production Workers
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Dec 2017
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Source: J Occup Environ Med. 59(Suppl 12):S28-S35.
Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective
The aim of this study was to investigate lung function among toluene diisocyanate (TDI) production workers.
Methods
One hundred ninety-seven U.S workers performed spirometry from 2006 through 2012. Results were compared within the study cohort and with U.S. population measures. A mixed-effects model assessed factors affecting repeated forced expiratory volume in 1 second (FEV1) measurements.
Results
The cohort’s mean FEV1 and forced vital capacity (FVC) percent reference values, although greater than 90%, were significantly lower and the prevalence of abnormal spirometry (predominantly restrictive pattern) was significantly higher than in the U.S. population. Differences in lung function among workers with higher cumulative TDI exposure were in the direction of an exposure effect, but not significant.
Conclusion
We found little evidence of an adverse effect of TDI exposure on longitudinal spirometry in these workers. The association between TDI exposure and the increasing prevalence of a restrictive pattern needs further exploration.
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Subjects:
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Source:
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Pubmed ID:29200136
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Pubmed Central ID:PMC5763545
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Document Type:
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Funding:
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Volume:59
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Main Document Checksum:
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Download URL:
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File Type:
[PDF-124.38 KB]
Supporting Files
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