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Population
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6 2018
Source: J Occup Environ Med. 60(6):496-506 -
Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objectives:
The butter flavoring additive, diacetyl (DA), can cause bronchiolitis obliterans (BO) by inhalation. A risk assessment was performed using data from a microwave popcorn manufacturing plant.
Methods:
Current employees’ medical history and pulmonary function tests together with air sampling over a 2.7-year period were used to analyze forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). The exposure responses for declining pulmonary function and for possible early onset of BO were estimated using multiple regression methods. Several exposure metrics were investigated; benchmark dose and excess lifetime risk of impairment were calculated.
Results:
Forty-six percent of the population had less than 6 months exposure to DA. Percent-of-predicted FEV1 declined with cumulative exposure (0.40 per ppm-yr, P < 10−7) as did percent FEV1/FVC (0.13 per ppm-yr, P = 0.0004). Lifetime respiratory impairment prevalence of one per thousand resulted from 0.005 ppm DA and one per thousand lifetime incidence of impairment was predicted for 0.002 ppm DA.
Conclusion:
DA exposures, often exceeding 1 ppm in the past, place workers at high risk of pulmonary impairment.
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Keywords:
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Pubmed ID:29443707
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Pubmed Central ID:PMC6110529
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Document Type:
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