Details:

Alternative Title:
J Occup Environ Med
Personal Author:
Park, Robert M.; Gilbert, Stephen J.;
Park, Robert M.; Gilbert, Stephen J.; Less -
Description:
Objectives: The butter flavoring additive, diacetyl (DA), can cause bronchiolitis obliterans (BO) by inhalation. A risk assessment was performed using data from a microwave popcorn manufacturing plant. Methods: Current employees’ medical history and pulmonary function tests together with air sampling over a 2.7-year period were used to analyze forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). The exposure responses for declining pulmonary function and for possible early onset of BO were estimated using multiple regression methods. Several exposure metrics were investigated; benchmark dose and excess lifetime risk of impairment were calculated. Results: Forty-six percent of the population had less than 6 months exposure to DA. Percent-of-predicted FEV1 declined with cumulative exposure (0.40 per ppm-yr, P < 10−7) as did percent FEV1/FVC (0.13 per ppm-yr, P = 0.0004). Lifetime respiratory impairment prevalence of one per thousand resulted from 0.005 ppm DA and one per thousand lifetime incidence of impairment was predicted for 0.002 ppm DA. Conclusion: DA exposures, often exceeding 1 ppm in the past, place workers at high risk of pulmonary impairment.
Subject:
[+]
Article
Benchmark Dose
Bronchiolitis Obliterans
Flavorings
Lifetime Risk
Susceptibility

Source:
J Occup Environ Med. 60(6):496-506.;
Pubmed ID:
29443707
Pubmed Central ID:
PMC6110529
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:616517927ae7be4c837c9b3a9a77fb6b42aa5f22f58f65d48036a0d08e0e972b
File Type:

Supporting Files

• 	nihms-983332-f0001.gif	gif
  	nihms-983332-f0001.jpg	jpeg
  	nihms-983332-f0002.gif	gif
  	nihms-983332-f0002.jpg	jpeg
  	nihms-983332.nxml	xml

More +