Pulmonary Impairment and Risk Assessment in a Diacetyl-Exposed Population
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Pulmonary Impairment and Risk Assessment in a Diacetyl-Exposed Population

Filetype[PDF-694.59 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      J Occup Environ Med
    • Personal Author:
    • Description:
      Objectives:

      The butter flavoring additive, diacetyl (DA), can cause bronchiolitis obliterans (BO) by inhalation. A risk assessment was performed using data from a microwave popcorn manufacturing plant.

      Methods:

      Current employees’ medical history and pulmonary function tests together with air sampling over a 2.7-year period were used to analyze forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). The exposure responses for declining pulmonary function and for possible early onset of BO were estimated using multiple regression methods. Several exposure metrics were investigated; benchmark dose and excess lifetime risk of impairment were calculated.

      Results:

      Forty-six percent of the population had less than 6 months exposure to DA. Percent-of-predicted FEV1 declined with cumulative exposure (0.40 per ppm-yr, P < 10−7) as did percent FEV1/FVC (0.13 per ppm-yr, P = 0.0004). Lifetime respiratory impairment prevalence of one per thousand resulted from 0.005 ppm DA and one per thousand lifetime incidence of impairment was predicted for 0.002 ppm DA.

      Conclusion:

      DA exposures, often exceeding 1 ppm in the past, place workers at high risk of pulmonary impairment.

    • Subject:
    • Source:
      J Occup Environ Med. 60(6):496-506.
    • Pubmed ID:
      29443707
    • Pubmed Central ID:
      PMC6110529
    • Document Type:
      Journal Article
    • Funding:
      CC999999/Intramural CDC HHS/United States
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

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