Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Collins, James J. ; Anteau, Steve ; Conner, Patrick R. ; Cassidy, Laura D. ; Doney, Brent ; Wang, Mei Lin ; Kurth, Laura ; Carson, Michael ; Molenaar, Don ; Redlich, Carrie A. ; Storey, Eileen
• Description:
  Objective
  
  This study examines asthma risk in facilities producing toluene diisocyanate (TDI).
  
  Methods
  
  A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures.
  
  Results
  
  The incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR] = 2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR = 1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68).
  
  Conclusions
  
  There is evidence that cumulative and peak exposures are associated with TDI-induced asthma.
  
  
• Subjects:
  Adult Aged Air Pollutants, Occupational Article Asthma, Occupational Chemical Industry Female Forced Expiratory Volume Humans Incidence Male Middle Aged Occupational Exposure Odds Ratio Odorants Time Factors Toluene 2,4-Diisocyanate United States Young Adult

  More +
• Source:
  J Occup Environ Med. 59(Suppl 12):S22-S27.
• Pubmed ID:
  29200135
• Pubmed Central ID:
  PMC5763544
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  59
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:358acbefc7a03bc638882165ad8184fc11c46d2c74aba3bf516d43a6d6ad8ae3
• Download URL:
  https://stacks.cdc.gov/view/cdc/50861/cdc_50861_DS1.pdf
• File Type:
  [PDF - 82.32 KB ]