Details:

Alternative Title:
Cancer Causes Control
Personal Author:
Press, David J. ; McKinley, Meg ; Deapen, Dennis ; Clarke, Christina A. ; Gomez, Scarlett Lin
Press, David J. ; McKinley, Meg ; Deapen, Dennis ; Clarke, Christina A. ; Gomez, Scarlett Lin Less -
Description:
Purpose

Trichloroethylene (TCE) is an industrial solvent associated with liver cancer, kidney cancer, and non- Hodgkin’s lymphoma (NHL). It is unclear whether an excess of TCE-associated cancers have occurred surrounding the Middlefield–Ellis–Whisman Superfund site in Mountain View, California. We conducted a population- based cancer cluster investigation comparing the incidence of NHL, liver, and kidney cancers in the neighborhood of interest to the incidence among residents in the surrounding four-county region.

Methods

Case counts and address information were obtained using routinely collected data from the Greater Bay Area Cancer Registry, part of the Surveillance, Epidemiology, and End Results program. Population denominators were obtained from the 1990, 2000, and 2010 US censuses. Standardized incidence ratios (SIRs) with two- sided 99 % confidence intervals (CIs) were calculated for time intervals surrounding the US Censuses.

Results

There were no statistically significant differences between the neighborhood of interest and the larger region for cancers of the liver or kidney. A statistically significant elevation was observed for NHL during one of the three time periods evaluated (1996–2005: SIR = 1.8, 99 % CI 1.1–2.8). No statistically significant NHL elevation existed in the earlier 1988–1995 (SIR = 1.3, 99 % CI 0.5–2.6) or later 2006–2011 (SIR = 1.3, 99 % CI 0.6–2.4) periods.

Conclusion

There is no evidence of an increased incidence of liver or kidney cancer, and there is a lack of evidence of a consistent, sustained, or more recent elevation in NHL occurrence in this neighborhood. This evaluation included existing cancer registry data, which cannot speak to specific exposures incurred by past or current residents of this neighborhood.


Subjects:
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Article Cancer Cluster Censuses Environmental Exposure Female Hazardous Waste Sites Humans Incidence Industry Kidney Kidney Neoplasms Liver Liver Neoplasms Lymphoma, Non-Hodgkin Male Non-Hodgkin’s Lymphoma SEER Program Solvents Superfund Trichloroethylene
Source:
Cancer Causes Control. 27(5):607-613.
Pubmed ID:
26983615
Pubmed Central ID:
PMC5759954
Document Type:
Journal Article
Funding:
HHSN261201000034C/PHS HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; 1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000140C/PHS HHS/United States ; ... More +
HHSN261201000034C/PHS HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; 1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000140C/PHS HHS/United States ; N01 PC035137/PC/NCI NIH HHS/United States Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ab2d344396eeeb248ccf9a29093c533783e9be6ee0dc29f744d8292ab8648fcf
Download URL:
https://stacks.cdc.gov/view/cdc/50781/cdc_50781_DS1.pdf
File Type:

Supporting Files

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