Residential cancer cluster investigation nearby a Superfund Study Area with trichloroethylene contamination

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Press, David J. ; McKinley, Meg ; Deapen, Dennis ; Clarke, Christina A. ; Gomez, Scarlett Lin
• Description:
  Purpose
  
  Trichloroethylene (TCE) is an industrial solvent associated with liver cancer, kidney cancer, and non- Hodgkin’s lymphoma (NHL). It is unclear whether an excess of TCE-associated cancers have occurred surrounding the Middlefield–Ellis–Whisman Superfund site in Mountain View, California. We conducted a population- based cancer cluster investigation comparing the incidence of NHL, liver, and kidney cancers in the neighborhood of interest to the incidence among residents in the surrounding four-county region.
  
  Methods
  
  Case counts and address information were obtained using routinely collected data from the Greater Bay Area Cancer Registry, part of the Surveillance, Epidemiology, and End Results program. Population denominators were obtained from the 1990, 2000, and 2010 US censuses. Standardized incidence ratios (SIRs) with two- sided 99 % confidence intervals (CIs) were calculated for time intervals surrounding the US Censuses.
  
  Results
  
  There were no statistically significant differences between the neighborhood of interest and the larger region for cancers of the liver or kidney. A statistically significant elevation was observed for NHL during one of the three time periods evaluated (1996–2005: SIR = 1.8, 99 % CI 1.1–2.8). No statistically significant NHL elevation existed in the earlier 1988–1995 (SIR = 1.3, 99 % CI 0.5–2.6) or later 2006–2011 (SIR = 1.3, 99 % CI 0.6–2.4) periods.
  
  Conclusion
  
  There is no evidence of an increased incidence of liver or kidney cancer, and there is a lack of evidence of a consistent, sustained, or more recent elevation in NHL occurrence in this neighborhood. This evaluation included existing cancer registry data, which cannot speak to specific exposures incurred by past or current residents of this neighborhood.
  
  
• Subjects:
  Censuses Environmental Exposure Female Hazardous Waste Sites Humans Incidence Industry Kidney Neoplasms Liver Neoplasms Lymphoma, Non-Hodgkin Male SEER Program Solvents Trichloroethylene

  More +
• Source:
  Cancer Causes Control. 27(5):607-613.
• Pubmed ID:
  26983615
• Pubmed Central ID:
  PMC5759954
• Document Type:
  Journal Article
• Funding:
  HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PC,CA/None/None ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; 1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; HHSN261201000140C/PHS HHS/United States ; N01 PC035137/PC/NCI NIH HHS/United States
• Place as Subject:
  California
• Volume:
  27
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ab2d344396eeeb248ccf9a29093c533783e9be6ee0dc29f744d8292ab8648fcf
• Download URL:
  https://stacks.cdc.gov/view/cdc/50781/cdc_50781_DS1.pdf
• File Type:
  [PDF - 237.73 KB ]