Air Pollution and Subclinical Interstitial Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Air-Lung Study

Details

• Alternative Title:
  Eur Respir J
• Personal Author:
  Sack, Coralynn ; Vedal, Sverre ; Sheppard, Lianne ; Raghu, Ganesh ; Barr, R Graham ; Podolanczuk, Anna ; Doney, Brent ; Hoffman, Eric A ; Gassett, Amanda ; Hinckley-Stukovsky, Karen ; Williams, Kayleen ; Kawut, Steve ; Lederer, David J ; Kaufman, Joel D
• Description:
  We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM|), nitrogen oxides (NO|), nitrogen dioxide (NO|) and ozone (O|)) at each home. A total of 5495 participants underwent serial assessment of HAAs by cardiac CT; 2671 participants were assessed for ILAs using full lung CT at the 10-year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site.The odds of ILAs increased 1.77-fold per 40 ppb increment in NO| (95% CI 1.06 to 2.95, p = 0.03). There was an overall trend towards an association between higher exposure to NO| and greater progression of HAAs (0.45% annual increase in HAAs per 40 ppb increment in NO|; 95% CI -0.02 to 0.92, p = 0.06). Associations of ambient fine particulate matter (PM|), NO| and NO| concentrations with progression of HAAs varied by race/ethnicity (p = 0.002, 0.007, 0.04, respectively, for interaction) and were strongest among non-Hispanic white people.We conclude that ambient air pollution exposures were associated with subclinical ILD.
• Subjects:
  Aged Air Pollution Environmental Exposure Ethnicity Female Humans Logistic Models Lung Diseases, Interstitial Male Middle Aged Multivariate Analysis Nitrogen Dioxide Nitrogen Oxides Ozone Particulate Matter Prospective Studies Risk Assessment Spatio-Temporal Analysis Tomography, X-Ray Computed White People

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• Source:
  Eur Respir J. 50(6)
• Pubmed ID:
  29217611
• Pubmed Central ID:
  PMC5726423
• Document Type:
  Journal Article
• Funding:
  N01 HC095166/HC/WHI NIH HHS/United States ; N01HC95160/HL/NHLBI NIH HHS/United States ; N01HC95163/HL/NHLBI NIH HHS/United States ; UL1 TR001079/TR/NCATS NIH HHS/United States ; N01 HC095164/HC/WHI NIH HHS/United States ; N01HC95169/HL/NHLBI NIH HHS/United States ; R01 HL077612/HL/NHLBI NIH HHS/United States ; K24 ES013195/ES/NIEHS NIH HHS/United States ; N01 HC095160/HC/WHI NIH HHS/United States ; N01HC95164/HL/NHLBI NIH HHS/United States ; N01HC95162/HL/NHLBI NIH HHS/United States ; N01HC95168/HL/NHLBI NIH HHS/United States ; P50 ES015915/ES/NIEHS NIH HHS/United States ; N01 HC095168/HC/WHI NIH HHS/United States ; P30 ES007033/ES/NIEHS NIH HHS/United States ; N01HC95165/HL/NHLBI NIH HHS/United States ; N01HC95159/HL/NHLBI NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; N01HC95161/HL/NHLBI NIH HHS/United States ; N01 HC095169/HC/NHLBI NIH HHS/United States ; N01 HC095165/HC/WHI NIH HHS/United States ; T32 HL007287/HL/NHLBI NIH HHS/United States ; N01 HC095161/HC/WHI NIH HHS/United States ; N01HC95167/HL/NHLBI NIH HHS/United States ; UL1 TR000040/TR/NCATS NIH HHS/United States ; K24 HL131937/HL/NHLBI NIH HHS/United States ; R01 HL103676/HL/NHLBI NIH HHS/United States ; N01HC95166/HL/NHLBI NIH HHS/United States ; N01 HC095162/HC/NHLBI NIH HHS/United States ; N01 HC095163/HC/WHI NIH HHS/United States ; N01 HC095159/HC/WHI NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  50
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:26cdda8ae695df104a569746d226677c86e2d38b4aa40af2af7c618bafb85844
• Download URL:
  https://stacks.cdc.gov/view/cdc/50707/cdc_50707_DS1.pdf
• File Type:
  [PDF - 413.71 KB ]