Air Pollution and Subclinical Interstitial Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Air-Lung Study

Details

• Personal Author:
  Barr RG ; Doney B ; Gassett A ; Hinckley-Stukovsky K ; Hoffman EA ; Kaufman JD ; Kawut S ; Lederer DJ ; Podolanczuk A ; Raghu G ; Sack C ; Sheppard L ; Vedal S ; Williams K
• Description:
  We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT). We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM2.5), nitrogen oxides (NOx), nitrogen dioxide (NO2) and ozone (O3)) at each home. A total of 5495 participants underwent serial assessment of HAAs by cardiac CT; 2671 participants were assessed for ILAs using full lung CT at the 10-year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site. The odds of ILAs increased 1.77-fold per 40 ppb increment in NOx (95% CI 1.06 to 2.95, p = 0.03). There was an overall trend towards an association between higher exposure to NOx and greater progression of HAAs (0.45% annual increase in HAAs per 40 ppb increment in NOx; 95% CI -0.02 to 0.92, p = 0.06). Associations of ambient fine particulate matter (PM2.5), NOx and NO2 concentrations with progression of HAAs varied by race/ethnicity (p = 0.002, 0.007, 0.04, respectively, for interaction) and were strongest among non-Hispanic white people. We conclude that ambient air pollution exposures were associated with subclinical ILD. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Environmental Exposure Lung Lung Diseases Nitrogen Dioxide Occupational Health Ozone Particulate Matter Race Factors Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Air Pollution Air Quality Cohort Studies Community Based Environmental Exposure Lung Disease Lung Disorders Medical Screening Nitrogen Dioxide Nitrogen Oxides Particle Size Particulates Pollutants Pollution Racial Factors Regression Analysis Scanning Techniques Surveillance

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• ISSN:
  0903-1936
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 7 ; Pennsylvania ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  6
• NIOSHTIC Number:
  nn:20050810
• Citation:
  Eur Respir J 2017 Dec; 50(6):1700559
• Contact Point Address:
  David J. Lederer, Room 3-321A, Columbia University Medical Center, 161 Fort Washington Avenue, New York, NY 10032, USA
• Email:
  dl427@cumc.columbia.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Respiratory Journal
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3e2d5f947ad7b710b076c527d3b3eb052921deb40f9b5004140018101b3f8d0234554b5589986bd6ead1dc836612e507763bc07fcd9a65b8b94fd7a49803b1c3
• Download URL:
  https://stacks.cdc.gov/view/cdc/211022/cdc_211022_DS1.pdf
• File Type:
  [PDF - 363.84 KB ]