Details:

Alternative Title:
J Gen Virol
Personal Author:
Ledermann, Jeremy P. ; Zeidner, Nord ; Borland, Erin M. ; Mutebi, John-Paul ; Lanciotti, Robert S. ; ... More +
Ledermann, Jeremy P. ; Zeidner, Nord ; Borland, Erin M. ; Mutebi, John-Paul ; Lanciotti, Robert S. ; Miller, Barry R. ; Lutwama, Julius J. ; Tendo, Joseph M. ; Andama, Vincent ; Powers, Ann M. Less -
Description:
Sunguru virus (SUNV), a novel virus belonging to the highly diverse Rhabdoviridae family, was isolated from a domestic chicken in the district of Arua, Uganda, in 2011. This is the first documented isolation of a rhabdovirus from a chicken. SUNV is related to, but distinct from, Boteke virus and other members of the unclassified Sandjimba group. The genome is 11056 nt in length and contains the five core rhabdovirus genes plus an additional C gene (within the ORF of a phosphoprotein gene) and a small hydrophobic protein (between the matrix and glycoprotein genes). Inoculation of vertebrate cells with SUNV resulted in significant viral growth, with a peak titre of 7.8 log10 p.f.u. ml(-1) observed in baby hamster kidney (BHK) cells. Little to no growth was observed in invertebrate cells and in live mosquitoes, with Anopheles gambiae mosquitoes having a 47.4% infection rate in the body but no dissemination of the virus to the salivary glands; this suggests that this novel virus is not arthropod borne as some other members of the family Rhabdoviridae.
Subjects:
[+]
Animals Anopheles Article Cell Line Chickens Cricetinae Genes, Viral Genome, Viral Molecular Sequence Data Rhabdoviridae Rhabdoviridae Infections RNA, Viral Salivary Glands Sequence Analysis, DNA Viral Load
Source:
J Gen Virol. 95(Pt 7):1436-1443
Pubmed ID:
24718834
Pubmed Central ID:
PMC5747356
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Uganda
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3346297cac1268b733bfbce160b15f4d0332e1c5dd7fc34d98de4ad96bf64560
Download URL:
https://stacks.cdc.gov/view/cdc/50652/cdc_50652_DS1.pdf
File Type:

Supporting Files

• 	NIHMS925744-supplement-supplemental.pdf	pdf
  	nihms925744.nxml	xml
  	nihms925744f1.gif	gif
  	nihms925744f1.jpg	jpeg
  	nihms925744f2.gif	gif
  	nihms925744f2.jpg	jpeg
  	nihms925744f3.gif	gif
  	nihms925744f3.jpg	jpeg

More +