Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women

Details

• Alternative Title:
  Menopause
• Personal Author:
  Boneva, Roumiana S. ; Lin, Jin-Mann S. ; Unger, Elizabeth R.
• Description:
  Objective
  
  This study aims to examine whether gynecologic conditions are associated with chronic fatigue syndrome (CFS).
  
  Methods
  
  This study includes a subset of 157 women from a population-based case-control study in Georgia, United States, conducted in 2004-2009. Gynecologic history was collected using a self-administered questionnaire. Crude odds ratios (ORs) with 95% CIs and ORs adjusted for body mass index and other covariates, where relevant, were estimated for gynecologic conditions between 84 CFS cases and 73 healthy controls.
  
  Results
  
  Cases and controls were of similar age. Women with CFS reported significantly more gynecologic conditions and surgical operations than controls: menopause status (61.9% vs 37.0%; OR, 2.37; 95% CI, 1.21-4.66), earlier mean age at menopause onset (37.6 vs 48.6 y; adjusted OR, 1.22; 95% CI, 1.09-1.36), excessive menstrual bleeding (73.8% vs 42.5%; adjusted OR, 3.33; 95% CI, 1.66-6.70), bleeding between periods (48.8% vs 23.3%; adjusted OR, 3.31; 95% CI, 1.60-6.86), endometriosis (29.8% vs 12.3%; adjusted OR, 3.67; 95% CI, 1.53-8.84), use of noncontraceptive hormonal preparations (57.1% vs 26.0%; adjusted OR, 2.95; 95% CI, 1.36-6.38), nonmenstrual pelvic pain (26.2% vs 2.7%; adjusted OR, 11.98; 95% CI, 2.57-55.81), and gynecologic surgical operation (65.5% vs 31.5%; adjusted OR, 3.33; 95% CI, 1.66-6.67), especially hysterectomy (54.8% vs 19.2%; adjusted OR, 3.23; 95% CI, 1.46-7.17). Hysterectomy and oophorectomy occurred at a significantly younger mean age in the CFS group than in controls and occurred before CFS onset in 71% of women with records of date of surgical operation and date of CFS onset.
  
  Conclusions
  
  Menstrual abnormalities, endometriosis, pelvic pain, hysterectomy, and early/surgical menopause are all associated with CFS. Clinicians should be aware of the association between common gynecologic problems and CFS in women. Further work is warranted to determine whether these conditions contribute to the development and/or perpetuation of CFS in some women.
  
  
• Subjects:
  Case-Control Studies Endometriosis Fatigue Syndrome, Chronic Female Georgia Humans Hysterectomy Menopause, Premature Menstruation Disturbances Middle Aged Odds Ratio Pelvic Pain Risk Factors Self Report

  More +
• Keywords:
  Chronic Fatigue Syndrome Menopause Menstrual Abnormalities Pelvic Pain
• Source:
  Menopause. 22(8):826-834
• Pubmed ID:
  25647777
• Pubmed Central ID:
  PMC5745581
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  22
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5b4565f6614caee16ad878f5cebefb430e23c97755921995498bce56f8b24c36
• Download URL:
  https://stacks.cdc.gov/view/cdc/50636/cdc_50636_DS1.pdf
• File Type:
  [PDF - 464.82 KB ]