Details:

Alternative Title:
J Infect Dis
Personal Author:
Jones, Enitra N. ; Amoah, Samuel ; Cao, Weiping ; Sambhara, Suryaprakash ; Gangappa, Shivaprakash
Jones, Enitra N. ; Amoah, Samuel ; Cao, Weiping ; Sambhara, Suryaprakash ; Gangappa, Shivaprakash Less -
Description:
Background

Protein energy malnutrition (PEM) increases susceptibility to infectious diseases, including influenza infection, but no studies have addressed the potential influences of PEM on the immunogenicity and protective efficacy of avian influenza A(H5N1) vaccine.

Methods

We investigated the role of PEM on vaccine-mediated protection after a lethal challenge with recombinant A(H5N1) virus using isocaloric diets providing either adequate protein (AP; 18% protein) or very low protein (VLP; 2% protein) in an established murine model of influenza vaccination.

Results

We demonstrated that mice maintained on a VLP diet succumb to lethal challenge at greater rates than mice maintained on an AP diet, despite comparable immunization regimens. Importantly, there was no virus-induced mortality in both VLP and AP groups of mice when either group was immunized with adjuvanted low-dose A(H5N1) subvirion vaccine.

Conclusions

Our results suggest that adjuvanted vaccination in populations where PEM is endemic may be one strategy to boost vaccination-promoted immunity and improve outcomes associated with highly pathogenic A(H5N1).


Subject:
[+]
Adjuvant
Adjuvants, Immunologic
Animals
Antibody Formation
Article
Avian Influenza
Diet, Protein-Restricted
Dietary Proteins
Disease Models, Animal
Female
Hemagglutination Inhibition Tests
Influenza
Influenza A Virus, H5N1 Subtype
Influenza Vaccines
Malnutrition
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections
Protein-Energy Malnutrition
Protein Energy Malnutrition
Vaccination
Virus

Source:
J Infect Dis. 216(Suppl 4):S560-S565
Pubmed ID:
28934453
Pubmed Central ID:
PMC5737928
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0af8a1368ccbbf2eac0abf38e7dee2a078f38ce1d8afa1f337dfdf27b14526bf
File Type:

Supporting Files

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