Rationale for Eliminating Staphylococcus Breakpoints for β-Lactam Agents Other Than Penicillin, Oxacillin or Cefoxitin, and Ceftaroline

Bard, Jennifer Dien; Hindler, Janet A.; Gold, Howard S.; Limbago, Brandi

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Rationale for Eliminating Staphylococcus Breakpoints for β-Lactam Agents Other Than Penicillin, Oxacillin or Cefoxitin, and Ceftaroline

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Jan 22 2014
By Bard, Jennifer Dien ; Hindler, Janet A. ; Gold, Howard S. ; ...

File Language:

English

Details

Alternative Title:

Clin Infect Dis
Personal Author:

Bard, Jennifer Dien ; Hindler, Janet A. ; Gold, Howard S. ; Limbago, Brandi
Description:

Due to the ongoing concern about the reliability of Staphylococcus breakpoints (interpretive criteria) for other β-lactam agents, the Clinical and Laboratory Standards Institute recently approved the elimination of all breakpoints for antistaphylococcal β-lactams except for penicillin, oxacillin or cefoxitin, and ceftaroline. Routine testing of penicillin and oxacillin or cefoxitin should be used to infer susceptibility for all β-lactams with approved clinical indications for staphylococcal infections. It is critical for laboratories to reject requests for susceptibility testing of other β-lactams against staphylococci and to indicate that susceptibility to these agents can be predicted from the penicillin and oxacillin or cefoxitin results. This article reviews β-lactam resistance mechanisms in staphylococci, current antimicrobial susceptibility testing and reporting recommendations for β-lactams and staphylococci, and microbiologic data and clinical data supporting the elimination of staphylococcal breakpoints for other β-lactam agents.
Subjects:

Anti-Bacterial Agents Beta-Lactam Resistance Beta-Lactams Cefoxitin Cephalosporins Humans Microbial Sensitivity Tests Oxacillin Penicillins Staphylococcal Infections Staphylococcus
Source:

Clin Infect Dis. 58(9):1287-1296.
Pubmed ID:

24457339
Pubmed Central ID:

PMC5734619
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Name as Subject:

United States. Food and Drug Administration.
Place as Subject:

United States
Volume:

58
Issue:

9
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:532ba40db810c020370a1e29edefbe7862cedad355fd9b79241d140409fa8700
Download URL:

https://stacks.cdc.gov/view/cdc/50572/cdc_50572_DS1.pdf
File Type:

[PDF - 350.24 KB ]

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File Language:

English

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