The broader autism phenotype in mothers is associated with increased discordance between maternal-reported and clinician-observed instruments that measure child autism spectrum disorder

Rubenstein, Eric; Edmondson-Pretzel, Rebecca; Windham, Gayle C.; Schieve, Laura A.; Wiggins, Lisa D.; DiGuiseppi, Carolyn; Olshan, Andrew F.; Howard, Annie G.; Pence, Brian W.; Young, Lisa; Daniels, Julie

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The broader autism phenotype in mothers is associated with increased discordance between maternal-reported and clinician-observed instruments that measure child autism spectrum disorder

Published Date:

Oct 2017

Source:

J Autism Dev Disord. 47(10):3253-3266.

Language:

English

[PDF-434.39 KB]

Details:

Alternative Title:

J Autism Dev Disord

Personal Author:

Rubenstein, Eric ; Edmondson-Pretzel, Rebecca ; Windham, Gayle C. ; Schieve, Laura A. ; Wiggins, Lisa D. ; ... More ▼

Description:

Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.

Subject:

[+]

Pubmed ID:

28748335

Pubmed Central ID:

PMC5728366

Document Type:

Journal Article

Funding:

P30 ES010126/ES/NIEHS NIH HHS/United States ; U10 DD000180/DD/NCBDD CDC HHS/United States ; U01 DD000746/DD/NCBDD CDC HHS/United States ; U10 DD000181/DD/NCBDD CDC HHS/United States ; U10 DD000184/DD/NCBDD CDC HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	NIHMS898596-supplement-Supplement.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms898596.nxml	text/xml
	nihms898596f1.gif	image/gif
	nihms898596f1.jpg	image/jpeg

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The broader autism phenotype in mothers is associated with increased discordance between maternal-reported and clinician-observed instruments that measure child autism spectrum disorder

The broader autism phenotype in mothers is associated with increased discordance between maternal-reported and clinician-observed instruments that measure child autism spectrum disorder

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