Prevalence of Developmental, Psychiatric, and Neurologic Conditions in Older Siblings of Children With and Without Autism Spectrum Disorder: Study to Explore Early Development.

Details

• Alternative Title:
  Journal of Autism and Developmental Disorders, 2025, v. 55, no. 11: Prevalence of Developmental, Psychiatric, and Neurologic Conditions in Older Siblings of Children With and Without Autism Spectrum Disorder: Study to Explore Early Development.
• Journal Article:
  Journal of Autism and Developmental Disorders
• Personal Author:
  Fields, Victoria L. ; Tian, Lin H. ; Wiggins, Lisa D. ; Soke, Gnakub N. ; Overwyk, Katherine ; Moody, Eric ; Reyes, Nuri ; Shapira, Stuart K. ; Schieve, Laura A.
• Description:
  This study evaluated developmental, psychiatric, and neurologic conditions among older siblings of children with and without autism spectrum disorder (ASD) to understand the extent of familial clustering of these diagnoses. Using data from the Study to Explore Early Development, a large multi-site case-control study, the analyses included 2,963 children aged 2-5 years with ASD, other developmental disabilities (DD group), and a population-based control group (POP). Percentages of index children with older siblings with select developmental, psychiatric, and neurologic conditions were estimated and compared across index child study groups using chi-square tests and multivariable modified Poisson regression. In adjusted analyses, children in the ASD group were significantly more likely than children in the POP group to have one or more older siblings with ASD, developmental delay, attention-deficit/hyperactivity disorder, intellectual disability, sensory integration disorder (SID), speech/language delays, or a psychiatric diagnosis (adjusted prevalence ratio aPR range: 1.4-3.7). Children in the DD group were significantly more likely than children in the POP group to have an older sibling with most of the aforementioned conditions, except for intellectual disability and psychiatric diagnosis (aPR range: 1.4-2.2). Children in the ASD group were significantly more likely than children in the DD group to have one or more older siblings with ASD, developmental delay, SID, or a psychiatric diagnosis (aPR range: 1.4-1.9). These findings suggest that developmental disorders cluster in families. Increased monitoring and screening for ASD and other DDs may be warranted when an older sibling has a DD diagnosis or symptoms.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Autism Spectrum Disorder
  • Siblings
  • Male
  • Female
  • Child, Preschool
  • Developmental Disabilities
  • Case-Control Studies
  • Prevalence
  • Mental Disorders
  More +
• Keywords:
  • Autism spectrum disorder
  • Developmental disabilities
  • Siblings
  • Conditions
  • Diagnoses
• Source:
  Journal of Autism and Developmental Disorders, 2025, v. 55, no. 11
• DOI:
  https://doi.org/10.1007/s10803-024-06464-6
• ISSN:
  0162-3257 ; 1573-3432
• Pubmed ID:
  39048798
• Pubmed Central ID:
  PMC11759717
• Document Type:
  Text
• Funding:
  U10 DD000901/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; Cooperative Agreement Number U10DD000498/Michigan State University/ ; Cooperative Agreement Number U01000748/Kaiser Foundation Research Institute (CA)/ ; Cooperative Agreement Number U01000749/University of North Carolina at Chapel Hill/ ; U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; Cooperative Agreement Number U10DD000180/Colorado Department of Public Health and Environment/ ; Cooperative Agreement Number U10DD000181/Kaiser Foundation Research Institute (CA)/ ; Cooperative Agreement Number U10DD000901/Michigan State University/ ; Cooperative Agreement Number U01000746/Johns Hopkins University/ ; U01 DD000750/DD/NCBDD CDC HHSUnited States/ ; Cooperative Agreement Number U10DD000184/University of North Carolina at Chapel Hill/ ; Cooperative Agreement Number U10DD000182/University of Pennsylvania/ ; Cooperative Agreement Number U01000752/University of Pennsylvania/ ; Cooperative Agreement Number U10DD000183/Johns Hopkins University/ ; Cooperative Agreement Number U01DD000750/University of Colorado Denver/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; Cooperative Agreement Number U01000750/University of Colorado Denver/
• Genre:
  Journal Article
• Pages in Document:
  3785-3797 (20 pdf pages)
• Volume:
  55
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/262074/cdc_262074_DS1.pdf
• File Type:
  [PDF - 379.43 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3c6488010201fa873208b2aaa959f921d2d9d6f77073b2c27c4ff6485d04f03d9d302cd99cbb29e3d564f98fb1dff5f57fd6777078fadfde5755015ee19e3f76