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Meningococcal Carriage Following a University Serogroup B Meningococcal Disease Outbreak and Vaccination Campaign with MenB-4C and MenB-FHbp — Oregon, 2015–2016
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11 27 2017
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Source: J Infect Dis. 216(9):1130-1140
[PDF-143.29 KB]
Details:
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Alternative Title:J Infect Dis
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Description:Background
Limited data exist on the impact of the serogroup B meningococcal (MenB) vaccines MenB-FHbp and MenB-4C on meningococcal carriage and herd protection. We therefore assessed meningococcal carriage following a MenB vaccination campaign in response to a university serogroup B meningococcal disease outbreak in 2015.
Methods
A convenience sample of students recommended for vaccination provided oropharyngeal swabs and completed questionnaires during four carriage surveys over 11 months. Isolates were tested by real-time PCR, slide agglutination, and whole genome sequencing. Vaccination history was verified via university records and the state immunization registry.
Results
A total of 4,225 oropharyngeal swabs were analyzed from 3,802 unique participants. Total meningococcal and genotypically serogroup B carriage prevalence among sampled students were stable at 11–17% and 1.2%–2.4% during each round, respectively; no participants carried the outbreak strain. Neither 1–3 doses of MenB-FHbp nor 1–2 doses of MenB-4C was associated with decreased total or serogroup B carriage prevalence.
Conclusions
While few participants completed the full MenB vaccination series, limiting analytic power, these data suggest that MenB-FHbp and MenB-4C do not have a large, rapid impact on meningococcal carriage and are unlikely to provide herd protection in the context of an outbreak response.
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Pubmed ID:28968661
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Pubmed Central ID:PMC5724767
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Volume:216
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Issue:9
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