Healthy vaccinee bias and MenB-FHbp vaccine effectiveness against gonorrhea

Details

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Abara, Winston E. ; Bernstein, Kyle T. ; Lewis, Felicia M.T. ; Pathela, Preeti ; Islam, Aras ; Eberhart, Michael ; Cheng, Iris ; Ternier, Alexandra ; Slutsker, Jennifer Sanderson ; Madera, Robbie ; Kirkcaldy, Robert
• Description:
  Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.
• Subjects:
  Antigens, Bacterial Gonorrhea Humans Meningococcal Vaccines Neisseria Meningitidis, Serogroup B Vaccine Efficacy
• Keywords:
  Gonorrhea MenB-4C MenB-FHbp OMV MenB Vaccines Vaccine Effectiveness
• Source:
  Sex Transm Dis. 50(6):e8-e10
• Pubmed ID:
  36863060
• Pubmed Central ID:
  PMC10175191
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  50
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7e465d54885a6aa4e47868b72b18177c12410c7ac3c304460389a2f11623bc2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/128340/cdc_128340_DS1.pdf
• File Type:
  [PDF - 70.01 KB ]