Healthy vaccinee bias and MenB-FHbp vaccine effectiveness against gonorrhea

Abara, Winston E.; Bernstein, Kyle T.; Lewis, Felicia M.T.; Pathela, Preeti; Islam, Aras; Eberhart, Michael; Cheng, Iris; Ternier, Alexandra; Slutsker, Jennifer Sanderson; Madera, Robbie; Kirkcaldy, Robert

doi:10.1097/OLQ.0000000000001793

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Healthy vaccinee bias and MenB-FHbp vaccine effectiveness against gonorrhea

6 01 2023
By Abara, Winston E. ; Bernstein, Kyle T. ; Lewis, Felicia M.T. ; ...
http://dx.doi.org/10.1097/OLQ.0000000000001793
Source: Sex Transm Dis. 50(6):e8-e10

[PDF-70.01 KB]

English

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Details:

Alternative Title:

Sex Transm Dis
Personal Author:

Abara, Winston E. ; Bernstein, Kyle T. ; Lewis, Felicia M.T. ; Pathela, Preeti ; Islam, Aras ; ... More +

Abara, Winston E. ; Bernstein, Kyle T. ; Lewis, Felicia M.T. ; Pathela, Preeti ; Islam, Aras ; Eberhart, Michael ; Cheng, Iris ; Ternier, Alexandra ; Slutsker, Jennifer Sanderson ; Madera, Robbie ; Kirkcaldy, Robert Less -
Description:

Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.
Subjects:

[+]

Antigens, Bacterial Gonorrhea Humans Meningococcal Vaccines Neisseria Meningitidis, Serogroup B Vaccine Efficacy
Keywords:

[+]

Gonorrhea MenB-4C MenB-FHbp OMV MenB Vaccines Vaccine Effectiveness
Source:

Sex Transm Dis. 50(6):e8-e10
Pubmed ID:

36863060
Pubmed Central ID:

PMC10175191
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:7e465d54885a6aa4e47868b72b18177c12410c7ac3c304460389a2f11623bc2c
Download URL:

https://stacks.cdc.gov/view/cdc/128340/cdc_128340_DS1.pdf
File Type:

nihms-1877330.nxml

xml

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