Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2013.12.018
Personal Author:
Bender, Thomas John ; Sharapov, Umid ; Utah, Okey ; Xing, Jian ; Hu, Dale ; ... More +
Bender, Thomas John ; Sharapov, Umid ; Utah, Okey ; Xing, Jian ; Hu, Dale ; Rybczynska, Jolanta ; Drobeniuc, Jan ; Kamili, Saleem ; Spradling, Philip R. ; Moorman, Anne C. Less -
Description:
Background

Failure to adhere to infection control guidelines, especially during assisted monitoring of blood glucose, has caused multiple hepatitis B outbreaks in assisted living facilities (ALFs). In conjunction with the response to such an outbreak at an ALF (“Facility X”) where most residents had neuropsychiatric disorders, we evaluated seroprotection rates conferred by hepatitis B vaccine and assessed the influence of demographic factors on vaccine response.

Methods

Residents were screened for hepatitis B and C infection, and those susceptible were vaccinated against hepatitis A and hepatitis B with one dose of TWINRIX™ (GSK) given at 0, 1, and 7 months. Blood samples were collected 1–2 months after receipt of the third vaccine dose to test for antibody to hepatitis B surface antigen (anti-HBs).

Results

Of the 27 residents who had post-vaccination blood specimens collected, 22 (81%) achieved anti-HBs concentrations ≥10 mIU/mL. Neither age nor neuropsychiatric comorbidity was a significant determinant of seroprotection. Geometric mean concentration was lower among residents aged 60–74 years (74.3 mIU/mL) than among residents aged 46–59 years (105.3 mIU/mL) but highest among residents aged ≥75 years (122.5 mIU/mL). The effect of diabetes on vaccination response could not be examined because 16/17 (94%) diabetic residents had HBV infection by the time of investigation.

Conclusions

Adult vaccine recipients of all ages, even those over 60 years of age, demonstrated a robust capacity for achieving hepatitis B seroprotection in response to the combined hepatitis A/hepatitis B vaccine. The role for vaccination in interrupting HBV transmission during an outbreak remains unclear, but concerns about age-related response to hepatitis B vaccine may be insufficient to justify foregoing vaccination of susceptible residents of ALFs.


Subject:
[+]
Adult
Age
Aged
Aged, 80 And Over
Assisted Living Facilities
Disease Outbreaks
Female
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B Vaccines
Humans
Male
Middle Aged
Neuropsychiatric

Source:
Vaccine. 32(7):852-856.
Pubmed ID:
24370706
Pubmed Central ID:
PMC5719870
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Virginia
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9991a31e8ed4a4ee483820483b40c3a08cdfeb95def938e40e27a6c4d2ac828c
File Type:

Supporting Files

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