Details:

Alternative Title:
Ann Epidemiol
Personal Author:
Interrante, Julia D. ; Ailes, Elizabeth C. ; Lind, Jennifer N. ; Anderka, Marlene ; Feldkamp, Marcia L. ; ... More +
Interrante, Julia D. ; Ailes, Elizabeth C. ; Lind, Jennifer N. ; Anderka, Marlene ; Feldkamp, Marcia L. ; Werler, Martha M. ; Taylor, Lockwood G. ; Trinidad, James ; Gilboa, Suzanne M. ; Broussard, Cheryl S. Less -
Corporate Authors:
The National Birth Defects Prevention Study
Description:
Purpose

To compare the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or opioids to the use of acetaminophen without NSAIDs or opioids with respect to associations with birth defects.

Methods

We used data from the National Birth Defects Prevention Study (1997–2011). Exposure was self-reported maternal analgesic use from the month before through the third month of pregnancy (periconceptional). Adjusted odds ratios (aORs) were calculated to examine associations with 16 birth defects.

Results

Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1.2–1.6). Opioids were associated with tetralogy of Fallot, perimembranous ventricular septal defect, and ventricular septal defect with atrial septal defect (aOR range, 1.8–2.3), whereas use of both opioids and NSAIDs was associated with gastroschisis, cleft palate, spina bifida, hypoplastic left heart syndrome, and pulmonary valve stenosis (aOR range, 2.0–2.9).

Conclusions

Compared to periconceptional use of acetaminophen, selected birth defects occurred more frequently among infants of women using NSAIDs and/or opioids. However, we could not definitely determine whether these risks relate to the drugs or to indications for treatment.


Subjects:
[+]
Abnormalities, Drug-Induced Acetaminophen Adult Analgesics Analgesics, Non-Narcotic Analgesics, Opioid Anti-inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Article Case-Control Studies Cleft Lip Cleft Palate Congenital Abnormalities Female Gastroschisis Humans Hypospadias Male Mothers Nonsteroidal Opioids Population Surveillance Pregnancy Teratogens Young Adult
Source:
Ann Epidemiol. 27(10):645-653.e2.
Pubmed ID:
28993061
Pubmed Central ID:
PMC5719491
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6cef11519a0dd9aa483722a56737c9fb185660aabe149fd642b9bdd31a9c1f5f
Download URL:
https://stacks.cdc.gov/view/cdc/50492/cdc_50492_DS1.pdf
File Type:

Supporting Files

• 	NIHMS918649-supplement-supplement_1.pdf	pdf
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