Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Interrante, Julia D. ; Ailes, Elizabeth C. ; Lind, Jennifer N. ; Anderka, Marlene ; Feldkamp, Marcia L. ; Werler, Martha M. ; Taylor, Lockwood G. ; Trinidad, James ; Gilboa, Suzanne M. ; Broussard, Cheryl S.
• Corporate Authors:
  The National Birth Defects Prevention Study
• Description:
  Purpose
  
  To compare the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or opioids to the use of acetaminophen without NSAIDs or opioids with respect to associations with birth defects.
  
  Methods
  
  We used data from the National Birth Defects Prevention Study (1997–2011). Exposure was self-reported maternal analgesic use from the month before through the third month of pregnancy (periconceptional). Adjusted odds ratios (aORs) were calculated to examine associations with 16 birth defects.
  
  Results
  
  Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1.2–1.6). Opioids were associated with tetralogy of Fallot, perimembranous ventricular septal defect, and ventricular septal defect with atrial septal defect (aOR range, 1.8–2.3), whereas use of both opioids and NSAIDs was associated with gastroschisis, cleft palate, spina bifida, hypoplastic left heart syndrome, and pulmonary valve stenosis (aOR range, 2.0–2.9).
  
  Conclusions
  
  Compared to periconceptional use of acetaminophen, selected birth defects occurred more frequently among infants of women using NSAIDs and/or opioids. However, we could not definitely determine whether these risks relate to the drugs or to indications for treatment.
  
  
• Subjects:
  Abnormalities, Drug-Induced Acetaminophen Adult Analgesics Analgesics, Non-Narcotic Analgesics, Opioid Anti-inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Article Case-Control Studies Cleft Lip Cleft Palate Congenital Abnormalities Female Gastroschisis Humans Hypospadias Male Mothers Nonsteroidal Opioids Population Surveillance Pregnancy Teratogens Young Adult

  More +
• Source:
  Ann Epidemiol. 27(10):645-653.e2.
• Pubmed ID:
  28993061
• Pubmed Central ID:
  PMC5719491
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  27
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6cef11519a0dd9aa483722a56737c9fb185660aabe149fd642b9bdd31a9c1f5f
• Download URL:
  https://stacks.cdc.gov/view/cdc/50492/cdc_50492_DS1.pdf
• File Type:
  [PDF - 612.45 KB ]