Mortality in a Combined Cohort of Uranium Enrichment Workers

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Yiin, James H. ; Anderson, Jeri L. ; Daniels, Robert D. ; Bertke, Stephen J. ; Fleming, Donald A. ; Tollerud, David J. ; Tseng, Chih-Yu ; Chen, Pi-Hsueh ; Waters, Kathleen M.
• Description:
  Objective
  
  To examine the patterns of cause-specific mortality and relationship between internal exposure to uranium and specific causes in a pooled cohort of 29,303 workers employed at three former uranium enrichment facilities in the United States with follow-up through 2011.
  
  Methods
  
  Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Internal comparison of the dose-response relation between selected outcomes and estimated organ doses was evaluated using regression models.
  
  Results
  
  External comparison with the U.S. population showed significantly lower SMRs in most diseases in the pooled cohort. Internal comparison showed positive associations of absorbed organ doses with multiple myeloma, and to a lesser degree with kidney cancer.
  
  Conclusion
  
  In general, these gaseous diffusion plant workers had significantly lower SMRs than the U.S. population. The internal comparison however, showed associations between internal organ doses and diseases associated with uranium exposure in previous studies.
  
  
• Keywords:
  Absorbed Organ Doses Adult Exposure-response Female Follow-Up Studies Gaseous Diffusion Healthy Worker Effect Humans Kidney Neoplasms Male Metallurgy Middle Aged Mortality Multiple Myeloma Occupational Diseases Occupational Exposure Radiation Radiation Exposure Standardized Mortality Ratios United States Uranium Uranium Enrichment Young Adult

  More +
• Source:
  Am J Ind Med. 60(1):96-108
• Pubmed ID:
  27753121
• Pubmed Central ID:
  PMC5708885
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  60
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:daef634b843f0b461887230b079a458e015ff7afc091fcb55a1e91f879ec3179
• Download URL:
  https://stacks.cdc.gov/view/cdc/50421/cdc_50421_DS1.pdf
• File Type:
  [PDF - 146.63 KB ]