OCCUPATIONAL EXPOSURE TO TRICHLOROETHYLENE AND CANCER RISK FOR WORKERS AT THE PADUCAH GASEOUS DIFFUSION PLANT

Details

• Alternative Title:
  Int J Occup Med Environ Health
• Personal Author:
  BAHR, DEBRA E. ; ALDRICH, TIMOTHY E. ; SEIDU, DAZAR ; BRION, GAIL M. ; TOLLERUD, DAVID J. ; MULDOON, SUSAN ; REINHART, NANCY ; YOUSEEFAGHA, AHMED ; MCKINNEY, PAUL ; HUGHES, THERESE ; CHAN, CAROLINE ; RICE, CAROL ; BREWER, DAVID E. ; FREYBERG, RONALD W. ; MOHLENKAMP, ADRIANE MOSER ; HAHN, KRISTEN ; HORNUNG, RICHARD ; HO, MONA ; DASTIDAR, ANIRUDDHA ; FREITAS, SAMANTHA ; SAMAN, DANIEL ; RAVDAL, HEGE ; SCUTCHFIELD, DOUGLAS ; EGER, KENNETH J. ; MINOR, STEVE
• Corporate Authors:
  THE PADUCAH GASEOUS DIFFUSION PLANT PROJECT TEAM
• Description:
  Objective
  
  The Paducah Gaseous Diffusion Plant (PGDP) became operational in 1952; it is located in the western part of Kentucky. We conducted a mortality study for adverse health effects that workers may have suffered while working at the plant, including exposures to chemicals.
  
  Materials and Methods
  
  We studied a cohort of 6820 workers at the PGDP for the period 1953 to 2003; there were a total of 1672 deaths to cohort members. Trichloroethylene (TCE) is a specific concern for this workforce; exposure to TCE occurred primarily in departments that clean the process equipment. The Life Table Analysis System (LTAS) program developed by NIOSH was used to calculate the standardized mortality ratios for the worker cohort and standardized rate ratio relative to exposure to TCE (the U.S. population is the referent for age-adjustment). LTAS calculated a significantly low overall SMR for these workers of 0.76 (95% CI: 0.72–0.79). A further review of three major cancers of interest to Kentucky produced significantly low SMR for trachea, bronchus, lung cancer (0.75, 95% CI: 0.72–0.79) and high SMR for Non-Hodgkin's lymphoma (NHL) (1.49, 95% CI: 1.02–2.10).
  
  Results
  
  No significant SMR was observed for leukemia and no significant SRRs were observed for any disease. Both the leukemia and lung cancer results were examined and determined to reflect regional mortality patterns. However, the Non-Hodgkin's Lymphoma finding suggests a curious amplification when living cases are included with the mortality experience.
  
  Conclusions
  
  Further examination is recommended of this recurrent finding from all three U.S. Gaseous Diffusion plants.
  
  
• Keywords:
  Adult Aged Aged, 80 And Over Cohort Studies Cohort Study Environmental Pollutants Extraction And Processing Industry Gaseous Diffusion Plant Healthy Worker Effect Humans Kentucky Male Middle Aged Neoplasms Occupational Exposure Trichloroethylene Young Adult

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• Source:
  Int J Occup Med Environ Health. 24(1):67-77
• Pubmed ID:
  21468904
• Pubmed Central ID:
  PMC5053621
• Document Type:
  Journal Article
• Funding:
  R01 OH007650/OH/NIOSH CDC HHSUnited States/ ; T32 ES011564/ES/NIEHS NIH HHSUnited States/
• Volume:
  24
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4a45d593a106eab42d5bce71c22e3bd889caf8522149e89b1f483bb2d1afe513
• Download URL:
  https://stacks.cdc.gov/view/cdc/42928/cdc_42928_DS1.pdf
• File Type:
  [PDF - 562.99 KB ]