Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control

Details

• Alternative Title:
  Antimicrob Resist Infect Control
• Personal Author:
  Magiorakos, A. P. ; Burns, K. ; Rodríguez Baño, J. ; Borg, M. ; Daikos, G. ; Dumpis, U. ; Lucet, J. C. ; Moro, M. L. ; Tacconelli, E. ; Simonsen, G. Skov ; Szilágyi, E. ; Voss, A. ; Weber, J. T.
• Description:
  Background
  
  Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are “at-risk” may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).
  
  Methods
  
  The guidance was created by a group of experts who were functioning independently of their organisations, during two meetings hosted by the European Centre for Disease Prevention and Control. A list of epidemiological risk factors placing patients “at-risk” for carriage with CRE was created by the experts. The conclusions of a systematic review on the prevention of spread of CRE, with the addition of expert opinion, were used to construct lists of core and supplemental infection prevention and control measures to be implemented for “at-risk” patients upon admission to healthcare settings.
  
  Results
  
  Individuals with the following profile are “at-risk” for carriage of CRE: a) a history of an overnight stay in a healthcare setting in the last 12 months, b) dialysis-dependent or cancer chemotherapy in the last 12 months, c) known previous carriage of CRE in the last 12 months and d) epidemiological linkage to a known carrier of a CRE.
  
  Conclusions
  
  Strengthening the microbiological capacity, surveillance and reporting of new cases of CRE in healthcare settings and countries is necessary to monitor the epidemiological situation so that, if necessary, the implemented CRE prevention strategies can be refined in a timely manner. Creating a large communication network to exchange this information would be helpful to understand the extent of the CRE reservoir and to prevent infections in healthcare settings, by applying the principles outlined here.
  
  Electronic supplementary material
  
  The online version of this article (10.1186/s13756-017-0259-z) contains supplementary material, which is available to authorized users.
  
  
• Subjects:
  Active Screening AMR Antimicrobial Resistance Carbapenem-resistant Enterobacteriaceae Core Measures CRE Guidelines Article Healthcare-associated Infections MDR-E Multidrug-resistant Enterobacteriaceae Supplemental Measures

  More +
• Source:
  Antimicrob Resist Infect Control. 6.
• Pubmed ID:
  29163939
• Pubmed Central ID:
  PMC5686856
• Document Type:
  Journal Article
• Volume:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:05eb05d9c9a1ca34ee81fd1a91d282bc74bc5bf41924e5a8abedfd528d731d46
• Download URL:
  https://stacks.cdc.gov/view/cdc/50270/cdc_50270_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]