Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0187466
Personal Author:
Diallo, Alpha Oumar ; Soeters, Heidi M. ; Yameogo, Issaka ; Sawadogo, Guetawendé ; Aké, Flavien ; ... More +
Diallo, Alpha Oumar ; Soeters, Heidi M. ; Yameogo, Issaka ; Sawadogo, Guetawendé ; Aké, Flavien ; Lingani, Clément ; Wang, Xin ; Bita, Andre ; Fall, Amadou ; Sangaré, Lassana ; Ouédraogo-Traoré, Rasmata ; Medah, Isaïe ; Bicaba, Brice ; Novak, Ryan T. Less -
Corporate Authors:
for the MenAfriNet Consortium
Description:
Background

Historically, Neisseria meningitidis serogroup A (NmA) caused large meningitis epidemics in sub-Saharan Africa. In 2010, Burkina Faso became the first country to implement a national meningococcal serogroup A conjugate vaccine (MACV) campaign. We analyzed nationwide meningitis surveillance data from Burkina Faso for the 5 years following MACV introduction.

Methods

We examined Burkina Faso’s aggregate reporting and national laboratory-confirmed case-based meningitis surveillance data from 2011–2015. We calculated incidence (cases per 100,000 persons), and described reported NmA cases.

Results

In 2011–2015, Burkina Faso reported 20,389 cases of suspected meningitis. A quarter (4,503) of suspected meningitis cases with cerebrospinal fluid specimens were laboratory-confirmed as either S. pneumoniae (57%), N. meningitidis (40%), or H. influenzae (2%). Average adjusted annual national incidence of meningococcal meningitis was 3.8 (range: 2.0–10.2 annually) and was highest among infants aged <1 year (8.4). N. meningitidis serogroup W caused the majority (64%) of meningococcal meningitis among all age groups. Only six confirmed NmA cases were reported in 2011–2015. Five cases were in children who were too young (n = 2) or otherwise not vaccinated (n = 3) during the 2010 MACV mass vaccination campaign; one case had documented MACV receipt, representing the first documented MACV failure.

Conclusions

Meningococcal meningitis incidence in Burkina Faso remains relatively low following MACV introduction. However, a substantial burden remains and NmA transmission has persisted. MACV integration into routine childhood immunization programs is essential to ensure continued protection.


Subjects:
[+]
Adolescent Child Child, Preschool Female Haemophilus Influenzae Humans Immunization Programs Infant Male Meningitis, Meningococcal Meningococcal Vaccines Neisseria Meningitidis, Serogroup A
Source:
PLoS One. 12(11).
Pubmed ID:
29095907
Pubmed Central ID:
PMC5667755
Document Type:
Journal Article
Place as Subject:
Burkina Faso
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:26d2caabde8bf41161a339328b337d8cbe7b207bf510ec727afb4932943db468
Download URL:
https://stacks.cdc.gov/view/cdc/50238/cdc_50238_DS1.pdf
File Type:

Supporting Files

• 	pone.0187466.nxml	xml
  	pone.0187466.s001.xlsx	xlsx
  	pone.0187466.s002.docx	docx
  	pone.0187466.s003.docx	docx
  	pone.0187466.t001.gif	gif
  	pone.0187466.t001.jpg	jpeg
  	pone.0187466.t002.gif	gif
  	pone.0187466.t002.jpg	jpeg
  	pone.0187466.t003.gif	gif
  	pone.0187466.t003.jpg	jpeg
  	pone.0187466.g001.gif	gif
  	pone.0187466.t004.gif	gif
  	pone.0187466.t004.jpg	jpeg
  	pone.0187466.g001.jpg	jpeg
  	pone.0187466.g002.gif	gif
  	pone.0187466.g002.jpg	jpeg
  	pone.0187466.g003.gif	gif
  	pone.0187466.g003.jpg	jpeg
  	pone.0187466.g004.gif	gif
  	pone.0187466.g004.jpg	jpeg

More +