Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0187466
Personal Author:
Diallo, Alpha Oumar; Soeters, Heidi M.; Yameogo, Issaka; Sawadogo, Guetawendé; Aké, Flavien; ... More +
Diallo, Alpha Oumar; Soeters, Heidi M.; Yameogo, Issaka; Sawadogo, Guetawendé; Aké, Flavien; Lingani, Clément; Wang, Xin; Bita, Andre; Fall, Amadou; Sangaré, Lassana; Ouédraogo-Traoré, Rasmata; Medah, Isaïe; Bicaba, Brice; Novak, Ryan T.; Less -
Corporate Authors:
for the MenAfriNet Consortium;
Description:
Background Historically, Neisseria meningitidis serogroup A (NmA) caused large meningitis epidemics in sub-Saharan Africa. In 2010, Burkina Faso became the first country to implement a national meningococcal serogroup A conjugate vaccine (MACV) campaign. We analyzed nationwide meningitis surveillance data from Burkina Faso for the 5 years following MACV introduction. Methods We examined Burkina Faso’s aggregate reporting and national laboratory-confirmed case-based meningitis surveillance data from 2011–2015. We calculated incidence (cases per 100,000 persons), and described reported NmA cases. Results In 2011–2015, Burkina Faso reported 20,389 cases of suspected meningitis. A quarter (4,503) of suspected meningitis cases with cerebrospinal fluid specimens were laboratory-confirmed as either S. pneumoniae (57%), N. meningitidis (40%), or H. influenzae (2%). Average adjusted annual national incidence of meningococcal meningitis was 3.8 (range: 2.0–10.2 annually) and was highest among infants aged <1 year (8.4). N. meningitidis serogroup W caused the majority (64%) of meningococcal meningitis among all age groups. Only six confirmed NmA cases were reported in 2011–2015. Five cases were in children who were too young (n = 2) or otherwise not vaccinated (n = 3) during the 2010 MACV mass vaccination campaign; one case had documented MACV receipt, representing the first documented MACV failure. Conclusions Meningococcal meningitis incidence in Burkina Faso remains relatively low following MACV introduction. However, a substantial burden remains and NmA transmission has persisted. MACV integration into routine childhood immunization programs is essential to ensure continued protection.
Subject:
[+]
Adolescent
Child
Child, Preschool
Female
Haemophilus Influenzae
Humans
Immunization Programs
Infant
Male
Meningitis, Meningococcal
Meningococcal Vaccines
Neisseria Meningitidis, Serogroup A

Source:
PLoS One. 12(11).;
Pubmed ID:
29095907
Pubmed Central ID:
PMC5667755
Document Type:
Journal Article;
Place as Subject:
Burkina Faso;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:26d2caabde8bf41161a339328b337d8cbe7b207bf510ec727afb4932943db468
File Type:

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