Multiple Reassorted Viruses as Cause of Highly Pathogenic Avian Influenza A(H5N8) Virus Epidemic, the Netherlands, 2016

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Beerens, Nancy ; Heutink, Rene ; Bergervoet, Saskia A. ; Harders, Frank ; Bossers, Alex ; Koch, Guus
• Description:
  In 2016, an epidemic of highly pathogenic avian influenza A virus subtype H5N8 in the Netherlands caused mass deaths among wild birds, and several commercial poultry farms and captive bird holdings were affected. We performed complete genome sequencing to study the relationship between the wild bird and poultry viruses. Phylogenetic analysis showed that the viruses are related to H5 clade 2.3.4.4 viruses detected in Russia in May 2016 but contained novel polymerase basic 2 and nucleoprotein gene segments and 2 different variants of the polymerase acidic segment. Molecular dating suggests that the reassortment events most likely occurred in wild birds in Russia or Mongolia. Furthermore, 2 genetically distinct H5N5 reassortant viruses were detected in wild birds in the Netherlands. Our study provides evidence for fast and continuing reassortment of H5 clade 2.3.4.4 viruses, which might lead to rapid changes in virus characteristics, such as pathogenicity, infectivity, transmission, and zoonotic potential.
• Subjects:
  Avian Influenza Virus Complete Genome Sequencing Epidemic H5N8 Highly Pathogenic Avian Influenza Virus Holland HPAIV Influenza Molecular Clock Multiple Reassorted Viruses As Cause Of Highly Pathogenic Avian Influenza A(H5N8) Virus Epidemic, The Netherlands, 2016 Outbreak Phylogenetic Analysis Reassortment Research Respiratory Infections The Netherlands Viruses Whole-genome Sequencing

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• Source:
  Emerg Infect Dis. 23(12):1974-1981.
• Pubmed ID:
  29148396
• Pubmed Central ID:
  PMC5708218
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6b62dcd863691b4fe00a93b015683c4ef3ff1d9acd06d2dc98541143bb25f272
• Download URL:
  https://stacks.cdc.gov/view/cdc/50206/cdc_50206_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]