Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Beerens, Nancy ; Heutink, Rene ; Bergervoet, Saskia A. ; Harders, Frank ; Bossers, Alex ; ... More +
Beerens, Nancy ; Heutink, Rene ; Bergervoet, Saskia A. ; Harders, Frank ; Bossers, Alex ; Koch, Guus Less -
Description:
In 2016, an epidemic of highly pathogenic avian influenza A virus subtype H5N8 in the Netherlands caused mass deaths among wild birds, and several commercial poultry farms and captive bird holdings were affected. We performed complete genome sequencing to study the relationship between the wild bird and poultry viruses. Phylogenetic analysis showed that the viruses are related to H5 clade 2.3.4.4 viruses detected in Russia in May 2016 but contained novel polymerase basic 2 and nucleoprotein gene segments and 2 different variants of the polymerase acidic segment. Molecular dating suggests that the reassortment events most likely occurred in wild birds in Russia or Mongolia. Furthermore, 2 genetically distinct H5N5 reassortant viruses were detected in wild birds in the Netherlands. Our study provides evidence for fast and continuing reassortment of H5 clade 2.3.4.4 viruses, which might lead to rapid changes in virus characteristics, such as pathogenicity, infectivity, transmission, and zoonotic potential.
Subject:
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Avian Influenza Virus
Complete Genome Sequencing
Epidemic
H5N8
Highly Pathogenic Avian Influenza Virus
Holland
HPAIV
Influenza
Molecular Clock
Multiple Reassorted Viruses As Cause Of Highly Pathogenic Avian Influenza A(H5N8) Virus Epidemic, The Netherlands, 2016
Outbreak
Phylogenetic Analysis
Reassortment
Research
Respiratory Infections
The Netherlands
Viruses
Whole-genome Sequencing

Source:
Emerg Infect Dis. 23(12):1974-1981.
Pubmed ID:
29148396
Pubmed Central ID:
PMC5708218
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6b62dcd863691b4fe00a93b015683c4ef3ff1d9acd06d2dc98541143bb25f272
File Type:

Supporting Files

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