Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus, Europe, January 20151

Cardeti, Giusy; Gruber, Cesare Ernesto Maria; Eleni, Claudia; Carletti, Fabrizio; Castilletti, Concetta; Manna, Giuseppe; Rosone, Francesca; Giombini, Emanuela; Selleri, Marina; Lapa, Daniele; Puro, Vincenzo; Di Caro, Antonino; Lorenzetti, Raniero; Scicluna, Maria Teresa; Grifoni, Goffredo; Rizzoli, Annapaola; Tagliapietra, Valentina; De Marco, Lorenzo; Capobianchi, Maria Rosaria; Autorino, Gian Luca

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Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus, Europe, January 20151

Supporting Files Public Domain

Dec 17 2017
By Cardeti, Giusy ; Gruber, Cesare Ernesto Maria ; Eleni, Claudia ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cardeti, Giusy ; Gruber, Cesare Ernesto Maria ; Eleni, Claudia ; Carletti, Fabrizio ; Castilletti, Concetta ; Manna, Giuseppe ; Rosone, Francesca ; Giombini, Emanuela ; Selleri, Marina ; Lapa, Daniele ; Puro, Vincenzo ; Di Caro, Antonino ; Lorenzetti, Raniero ; Scicluna, Maria Teresa ; Grifoni, Goffredo ; Rizzoli, Annapaola ; Tagliapietra, Valentina ; De Marco, Lorenzo ; Capobianchi, Maria Rosaria ; Autorino, Gian Luca
Description:

In January 2015, during a 3-week period, 12 captive Tonkean macacques at a sanctuary in Europe died. An orthopoxvirus infection was suspected because of negative-staining electron microscopy results. The diagnosis was confirmed by histology, virus isolation, and molecular analysis performed on different organs from all animals. An epidemiologic investigation was unable to define the infection source in the surrounding area. Trapped rodents were negative by virologic testing, but specific IgG was detected in 27.27% of small rodents and 14.28% of rats. An attenuated live vaccine was administered to the susceptible monkey population, and no adverse reactions were observed; a detectable humoral immune response was induced in most of the vaccinated animals. We performed molecular characterization of the orthopoxvirus isolate by next-generation sequencing. According to the phylogenetic analysis of the 9 conserved genes, the virus could be part of a novel clade, lying between cowpox and ectromelia viruses.
Subjects:

Cluster Analysis Cowpox Virus Diagnosis Ectromelia Virus Epidemiology Europe Fatal Outbreak In Tonkean Macaques Caused By Possibly Novel Orthopoxvirus, Europe, January 2015 Macaca Tonkeana Metagenomics Orthopoxvirus Infection Phylogeny Synopsis Tonkean Macaque Vaccination Viruses Zoonoses
Source:

Emerg Infect Dis. 23(12):1941-1949.
Pubmed ID:

28975882
Pubmed Central ID:

PMC5708245
Document Type:

Journal Article
Volume:

23
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:42883e9c216b0d82d4da20feadeb10e08198a10458f581f7ea7d1ce9377111c5
Download URL:

https://stacks.cdc.gov/view/cdc/50181/cdc_50181_DS1.pdf
File Type:

[PDF - 4.94 MB ]

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