Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Cardeti, Giusy ; Gruber, Cesare Ernesto Maria ; Eleni, Claudia ; Carletti, Fabrizio ; Castilletti, Concetta ; ... More +
Cardeti, Giusy ; Gruber, Cesare Ernesto Maria ; Eleni, Claudia ; Carletti, Fabrizio ; Castilletti, Concetta ; Manna, Giuseppe ; Rosone, Francesca ; Giombini, Emanuela ; Selleri, Marina ; Lapa, Daniele ; Puro, Vincenzo ; Di Caro, Antonino ; Lorenzetti, Raniero ; Scicluna, Maria Teresa ; Grifoni, Goffredo ; Rizzoli, Annapaola ; Tagliapietra, Valentina ; De Marco, Lorenzo ; Capobianchi, Maria Rosaria ; Autorino, Gian Luca Less -
Description:
In January 2015, during a 3-week period, 12 captive Tonkean macacques at a sanctuary in Italy died. An orthopoxvirus infection was suspected because of negative-staining electron microscopy results. The diagnosis was confirmed by histology, virus isolation, and molecular analysis performed on different organs from all animals. An epidemiologic investigation was unable to define the infection source in the surrounding area. Trapped rodents were negative by virologic testing, but specific IgG was detected in 27.27% of small rodents and 14.28% of rats. An attenuated live vaccine was administered to the susceptible monkey population, and no adverse reactions were observed; a detectable humoral immune response was induced in most of the vaccinated animals. We performed molecular characterization of the orthopoxvirus isolate by next-generation sequencing. According to the phylogenetic analysis of the 9 conserved genes, the virus could be part of a novel clade, lying between cowpox and ectromelia viruses.
Subject:
[+]
Cluster Analysis
Cowpox Virus
Diagnosis
Ectromelia Virus
Epidemiology
Fatal Outbreak In Tonkean Macaques Caused By Possibly Novel Orthopoxvirus, Italy, January 2015
Italy
Macaca Tonkeana
Metagenomics
Orthopoxvirus Infection
Phylogeny
Synopsis
Tonkean Macaque
Vaccination
Viruses
Zoonoses

Source:
Emerg Infect Dis. 23(12):1941-1949.
Pubmed ID:
28975882
Pubmed Central ID:
PMC5708245
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:42883e9c216b0d82d4da20feadeb10e08198a10458f581f7ea7d1ce9377111c5
File Type:

Supporting Files

• 	16-2098-F5.gif	gif
  	16-2098-F5.jpg	jpeg
  	16-2098-F6.gif	gif
  	16-2098-F6.jpg	jpeg
  	16-2098.nxml	xml
  	16-2098-F1.gif	gif
  	16-2098-F1.jpg	jpeg
  	16-2098-F2.gif	gif
  	16-2098-F2.jpg	jpeg
  	16-2098-F3.gif	gif
  	16-2098-F3.jpg	jpeg
  	16-2098-F4.gif	gif
  	16-2098-F4.jpg	jpeg

More +